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A cancer treatment found naturally in tropical rainforest tree species
Time of Update: 2022-10-20
"essayPractical synthesis of the therapeutic leads tigilanol tiglate and its analogues Researchers at Stanford University have discovered a rapid, sustainable way to synthesize a promising cancer-fighting compound in the lab.
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A new technology to prevent ductal obstruction in patients with hydrocephalus
Time of Update: 2022-10-20
essayContactless Ultrasonic Cavitation for the Prevention of Shunt Obstruction in Hydrocephalus: A Proof-of-Concept Study Image: A photo selected from the demo video (Video 2) showing cavitation in a hydrocephalus valve filled with water and graphite powder.
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Role of microbial-derived ethanol in nonalcoholic fatty liver
Time of Update: 2022-10-20
Inhibition of ADH increases the concentration of peripheral blood ethanol in patients with NAFLD by 15 times (IQR, 1.
Inhibition of ADH increases the concentration of peripheral blood ethanol in patients with NAFLD by 15 times (IQR, 1.
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Human neurons are transplanted into the brains of rats
Time of Update: 2022-10-20
"Pasca told Technology Review that the rats in the study did not show any evidence of advanced cognition or human behavior.
"Pasca told Technology Review that the rats in the study did not show any evidence of advanced cognition or human behavior.
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Nature improves the delivery of gene therapies to the central nervous system
Time of Update: 2022-10-20
The blood-brain barrier (BBB) is a formidable enemy of gene therapy. The blood-brain barrier is formed by cells tightly bound together, which prevents toxins and pathogens that may be present in the
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Li Peng's team revealed that the phospholipid transporter PITPNC1 regulates mitochondrial phospholipid homeostasis to maintain body temperature in mice
Time of Update: 2022-10-20
On September 23, 2022, the Li Peng team from the Institute of Metabolic and Integrative Biology of Fudan University published a paper entitled PITPNC1 promotes the thermogenesis of brown adipose tiss
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Nature solves a long-standing mystery about how cancer-promoting proteins lead to drug-resistant tumor growth
Time of Update: 2022-10-20
essayA PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction Image: Benjamin Myers, Ph. D.
essayA PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction Image: Benjamin Myers, Ph. D.
in the lab Image credit: Huntsman Cancer InstituteImage: Benjamin Myers, Ph. D.
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Innovative technology EZ Clear: Transparent imaging of whole organs in mice
Time of Update: 2022-10-20
Wythe, PhD, of Baylor College of Medicine has developed an innovative technology called EZ Clear, a simple and fast new method that speeds up the process of presenting tissues as optically transparent, enabling 3D imaging of entire intact tissues and even entire organs in just three simple steps.
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Cell Research: Single-cell chromatin accessibility sequencing technology based on a single molecule sequencing platform
Time of Update: 2022-10-20
On October 11, 2022, the Tang Fuyi research group of the Center for Biomedical Frontier Innovation (BIOPIC) of Peking University published a paper entitled scNanoATAC-seq: a long-read single-cell ATA
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Molecular Cell Weiguo Zhu/Yang Yang team discovered a novel mechanism by which cytosolic histone deacetylase SIRT6 promotes fatty acid oxidation
Time of Update: 2022-10-20
One of the most common chronic liver diseases is nonalcoholic fatty liver disease (NAFLD), which includes simple fatty liver and nonalcoholic steatohepatitis (NASH), a more serious metabolic liver di
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The plant of Kunming has made new progress in resisting the feeding of potato monophagous insects and broad-eating insects in jasmonic acid
Time of Update: 2022-10-20
The study suggests that increasing the endogenous JA-Ile content of plants can enhance potato resistance to broad-eating insects, and specialized insects such as PTM may have evolved effective detoxification mechanisms to counter JA-Ile-induced insect-resistant secondary metabolites。 Recently, the relevant research results are Elevating herbivore-induced JA-Ile enhances potato resistance to the polyphagous beet armyworm but not to the oligophagous potato tuber moth The title was published online in Pest Management Science, a leading journal in the field of agriculture and insects.
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This new compound can destroy the superbug MRSA!
Time of Update: 2022-10-20
Studies have shown that the compound not only directly destroys Staphylococcus aureus, but also restores the sensitivity of the multidrug-resistant strain of the bacterium to three important antibiotics (daptomycin, oxacillin, and vancomycin).
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Novel cell-free protein crystallization methods advancing structural biology
Time of Update: 2022-10-20
Image credit: Professor Takafumi UenoThe new cell-free protein crystallization (CFPC) method developed by Tokyo Institute of Technology, including direct protein crystallization, is an important advance in the field of structural biology.
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Successfully simulates the formation of coronavirus - genome cohesion and budding
Time of Update: 2022-10-20
"In this paper, using the coarse-grained model, we have been able to successfully mimic the formation of SARS-CoV-2: N proteins compress RNA, forming compact RNP complexes that interact with M proteins embedded in lipid membranes," Zandi said.
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Early life B cell programs such as affect long-term immune health
Time of Update: 2022-10-20
A new study by researchers at Lund University in Sweden provides new insights into the origin and development of B cells in the body and gut, with implications for long-term immune health.
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The conscious perception of sound consists of specialized neurons in the brain
Time of Update: 2022-10-20
When the brain perceives auditory stimuli under anesthesia, a collection of hundreds of neurons also appears, but only in the awake and conscious state do specific neurons appear and are associated with specific sounds.
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Open up a new direction for the treatment of hepatitis B virus
Time of Update: 2022-10-20
In 2016, a UNIGE team led by Michel Strubin, an associate professor at the Geneva Center for Inflammation Research in the Department of Microbiology and Molecular Medicine at the University of Michigan School of Medicine, revealed a mechanism critical to understanding the disease: When our immune system defends itself, a complex of six proteins called SMC5/6 present in our cells — the interdependent group — detects viral DNA 。 The virus then fights back, producing a special protein, protein X.
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The 12,111 SNPs affecting human height come from the largest genome-wide association study of 5.4 million individuals to date
Time of Update: 2022-10-20
Over the next 20 years, the GIANT consortium reported as many as 3,290 height-associated SNP variants at 712 sites in a GWAS database of nearly 700,000 sample sizes, but because the study focused on participants of European ancestry, the lack of diversity was a common problem in genetic research.
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The link between hypoxia and fetal hemoglobin
Time of Update: 2022-10-20
in Hematology, St. Jude Scientists at St. Jude Children's Research Hospital have shown how a protein responsible for adapting to a hypoxic environment (hypoxia) can lead to increased expression of hemoglobin (HbF) in adult fetuses.
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Single-cell chromatin accessibility sequencing technology based on single-molecule sequencing platform
Time of Update: 2022-10-20
On October 11, 2022, the Tang Fuyi research group of the Center for Biomedical Frontier Innovation (BIOPIC) of Peking University published a paper entitled scNanoATAC-seq: a long-read single-cell ATA
