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Cells: Research status and challenges of TCR-T cell therapy
Time of Update: 2022-10-31
These challenges include: (1) immunotoxicity caused by targeting normal tissue; (2) insufficient or transient expression of TCR in engineered T cells; (3) T cell depletion and dysfunction; (4) tumor immune evasion, and (5) most cancer patients lack effective tumor-specific antigens as targets.
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【CSCO 2022 Preview】Listen to Academician Shen Hongbing talk about how to use health and medical big data to conduct clinical medical research
Time of Update: 2022-10-31
com/s/ufFP_mJxQ_bpp6jSpyI1eg Electronic medical records, wearable devices, electronic examination reports.
com/s/ufFP_mJxQ_bpp6jSpyI1eg Electronic medical records, wearable devices, electronic examination reports.
com/s/ufFP_mJxQ_bpp6jSpyI1eg Electronic medical records, wearable devices, electronic examination reports.
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European Radiology: CEUS "live use" in diagnosing pancreatic ductal adenocarcinoma
Time of Update: 2022-10-31
Recently, a study published in the journal European Radiology evaluated the EFSUMB guidelines for the diagnostic performance and recommendations of CEUS clinical practice for solid pancreatic lesions, and further explored the ability of CEUS in the differential diagnosis and prognosis prediction of PDAC.
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Wonderful collection of Healthy China 2030-2022 inter-hospital exchange conference on standardized diagnosis and treatment of bowel cancer
Time of Update: 2022-10-31
In 2016, the Central Committee of the Communist Party of China and the State Council issued the "Healthy China 2030" Planning Outline, which clearly stated that It is required that the 5-year survival
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EJNMMI: A strong combination of low-dose radionuclides and PD-L1/CTLA-4 dual targeted immunosuppressant KN046 improves immunotherapy response rate
Time of Update: 2022-10-31
As a PD-L1/CTLA-4 Fc fusion bispecific antibody, KN046 has significant advantages in anti-tumor efficacyStudies have reported that low-dose ionizing radiation stimulation can be used for immune enhancement by inducing the release of tumor immunogenicity-associated antigens.
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European Radiology: Deep learning enables 3D MRCPs for IPMN patients to be "more selective, more exciting"
Time of Update: 2022-10-31
Recently, a study published in the journal European Radiology compared the difference between acquisition time and image quality obtained by IPMN patients using various techniques, and further clarified the clinical practical value of DLR, providing technical support for clinical accurate IPMN diagnosis and follow-up evaluation.
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More than 10 million people commute extremely: some people commute for 3 hours each way, commute for more than 20 minutes, and the chance of cancer is as high as 10%
Time of Update: 2022-10-31
Longer commutes can be harmful to health, while people who spend longer hours in a car may be exposed to higher concentrations of hazardous substances (CO, volatile organic compound VOCs, ozone, and flame retardants), and a significant proportion of people in California may inhale benzene and formaldehyde beyond safe limits.
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European Radiology: The use of radiomics in assessing response to whole-brain radiation therapy
Time of Update: 2022-10-31
Figure ROC curve comparison between training group (A) and validation group (B) to assess WBRT treatment responseThe radiology-clinical machine learning model containing CET1-w (3D) MR sequence features proposed in this study can be used to evaluate the treatment response of WBRT, where the SHAP method used can assist clinicians in guiding personalized WBRT strategies in patients with brain metastases.
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Nat Commun: Scientists have identified key new genes driving colon cancer
Time of Update: 2022-10-31
Recently, a research report published in the international journal Nature Communications entitled "A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma", Scientists from institutions such as Mount Sinai Medical College have identified a new gene that is important for colon cancer growth, while also finding that inflammation in the external environment around tumors may lead to the growth of tumor cells.
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JAMA Oncol: Anti-atecilizumab antibodies are associated with poor clinical prognosis in patients with advanced liver cancer
Time of Update: 2022-10-31
Progression-free survival and overall survival in patients with different ADA levels in both cohortsBoth in the discovery and validation cohorts, high ADA levels at C2D1 were associated with reduced response rates with Atezo/Bev treatment compared with patients with low ADA levels (found cohort: 34 versus 11 percent; Validation cohort: 29 versus 7 percent), shorter progression-free lifetime (HR: discovery cohort: 2.
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Targeted delivery of immune-activated cytokines inhibits the growth of GBM in mouse models
Time of Update: 2022-10-31
The results were published online in the July 2022 issue of Sci Transl Med. Research methods Based on the high expression of TIE2 in tumor-associated monocytes/macrophages, the researchers constructed the lentiviral vector Tie2-Ifna1-mirT for IFN-α delivery and further transfected the vector to hematopoietic stem cell HSCs. Engineered HSCs can achieve specific targeted delivery of IFN-α in tumors and verify therapeutic effects using mouse in situ tumor models.
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【CSCO 2022 Preview】CHOICE-01 research promotes precision treatment of lung cancer
Time of Update: 2022-10-31
com/s/BtA15kwZn3_XtHsRxgMQaw Compared with lung adenocarcinoma, patients with lung squamous cell carcinoma have a worse prognosis and are more challenging to treat.
com/s/BtA15kwZn3_XtHsRxgMQaw Compared with lung adenocarcinoma, patients with lung squamous cell carcinoma have a worse prognosis and are more challenging to treat.
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【CSCO 2022 Preview】Professor Qin Shukui leads the domestic multi-center pancreatic cancer drug treatment research
Time of Update: 2022-10-31
com/s/anoTZl6klgictFJr_ZDv7g Pancreatic cancer is a malignant tumor of the digestive system that is very difficult to diagnose and treat, and research progress has been slow, commonly known as the "king of cancers".
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【CSCO 2022 Prospect】IMpower010 research leads the reform of adjuvant therapy for early-stage non-small cell lung cancer
Time of Update: 2022-10-31
Lung cancer is one of the most life-threatening malignancies in a population. In recent years, the incidence of lung cancer has shown signs of increasing significantly in most countries, with non-smal
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European Radiology: white matter changes in patients with different prognosis after radiotherapy for nasopharyngeal carcinoma
Time of Update: 2022-10-31
Recently, a study published in the journal European Radiology delineated different patterns of longitudinal WM volume changes in patients with and without RNA in patients with nasopharyngeal carcinoma, and used machine learning methods to construct a predictive model of early WM volume changes after RN and RT.
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Int J Dermatol: Melanoma survivors are at increased risk of developing a second primary keratinocarcinoma
Time of Update: 2022-10-31
A meta-analysis published today in Int J Dermatol aims to comprehensively analyze the risk of developing keratinocarcinoma after primary melanoma.
A meta-analysis published today in Int J Dermatol aims to comprehensively analyze the risk of developing keratinocarcinoma after primary melanoma.
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European Radiology: This MRI manifestation enables noninvasive evaluation of axillary lymph nodes in patients with early-stage breast cancer
Time of Update: 2022-10-31
A main cohort; B Verify the queueThis study showed that MRI of tumor-associated mammary edema can be used as an important imaging predictive feature to improve the prediction performance of pathological axillary lymph node load in patients with early-stage breast cancer, and further assist in the evaluation and implementation of preoperative treatment plans.
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Patients with early-stage NSCLC treated with SBRT taking ARB antihypertensive drugs can extend survival to 96.7 months
Time of Update: 2022-10-31
A recent study published in the journal Cancer Biol Ther investigated patients with early-stage lung cancer who received SBRT taking ARB at the same time compared to those who did not take it , whether it shows an improvement in overall survival (OS) or relapse-free survival (RFS).
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Clin Cancer Res: ctDNA monitoring predicts treatment response and early progression risk for follicular lymphoma
Time of Update: 2022-10-31
EFS rate in ctDNA-positive or negative patients during follow-upctDNA levels before treatment, as haploid genomic equivalents (hGE/mL), were higher in patients who did not achieve a complete response (p=0.
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Cell Res: Finally figured it out! Kang Tiebang et al. of Sun Yat-sen University discovered the underlying mechanism of activated STING in intercellular metastasis to promote anti-tumor immunity
Time of Update: 2022-10-31
ILVs formed by inward budding of MVEs are mainly mediated by the mechanism of Syntenin-Alix-ESCRT-III or RAB31-FLOTs 。 Classic autophagy is a highly conserved process of self-digestion of cellular components that is essential for intracellular homeostasis and adaptive stress, and plays an important role in various physiological and pathological processes through selective or non-selective degradation of substrates, including protein aggregates, damaged mitochondria, endoplasmic reticulum, lipid droplets, and intracellular pathogens.
