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Small Methods: Li Yaping's team at Shanghai Institute of Materia Medica, regulates nanoparticles through cholesterol metabolism to improve the effect of tumor photodynamic-immunotherapy
Time of Update: 2022-11-14
In this study, a matrix metalloproteinase (MMP-2)-responsive pro-osmotic nanoparticle was developed, which simultaneously regulated the cholesterol metabolism behavior of CTLs and tumor cells by promoting intratumoral penetration of drugs, improving the function of CTLs, and synergistically enhancing the anti-tumor effect of photodynamic-immunotherapy.
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AlphaFold has met a strong competitor, and Facebook's Meta AI is more efficient and intelligent
Time of Update: 2022-11-14
01Meta AI: "autocomplete" protein structureWhat is Meta AI that Rost, a computational biologist at the Technical University of Munich in Germany, praised as "more efficient, simpler and cheaper"?In July 2022, the news that AlphaFold predicted about 220 million protein structures still seems to haunt us today.
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Soft Heart: "2022 Breast Cancer Elite Practice and Exchange Project - Hebei Station" was successfully held!
Time of Update: 2022-11-14
Executive Chairman: Professor Han Meng (Qinhuangdao First Hospital)Guest: Professor Wang Yingman (Affiliated Hospital of North China University of Science and Technology)Guest: Professor Zhang Wei (Cangzhou Central Hospital)Guest: Professor Song Cuiping (The Fourth Hospital of QinhuangdaoCommentator: Professor Huang Ruixue (Qinhuangdao Maternal and Child Health Care Hospital) Case 1 Sharing: Dr. Lv Linlin (Cancer Center, Affiliated Hospital of Hebei University of Engineering)This is a relatively young patient with HR+ advanced breast cancer, invasive ductal carcinoma of the left breast, pT1N0M0, stage I.
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The secret of elevated β-HCG and LDH and HBDH in men
Time of Update: 2022-11-14
PreambleHCG (humanchorionicgonadotropin), human chorionic gonadotropin, is a glycoprotein hormone secreted by the trophoblast cells of the placenta, composed of two subunits, α and β, a single subunit
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Lancet Oncol: Safety of low-dose, short-course radiotherapy before surgery for soft tissue sarcoma
Time of Update: 2022-11-14
The standard preoperative radiotherapy regimen for soft tissue sarcoma is 50 Gy divided into 25 sessions for 5 weeks and provides good local control, but major wound complications occur in about 35% of patients.
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European Radiology: How to reduce the rate of benign biopsies of breast BI-RADS 4A lesions?
Time of Update: 2022-11-14
Recently, a study published in the journal European Radiology explored the diagnostic performance of CEM combined with KS in DBT BI-RADS 4A lesions, providing technical support for reducing unnecessary breast biopsies.
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Clin Cancer Res: A Phase I study of Niraparib in combination with radium-223 in metastatic castration-resistant prostate cancer
Time of Update: 2022-11-14
safety profile of niraparib, a PARP inhibitor, in combination with Radium-223 for metastasis-resistant prostate cancer (mCRPCStudies included men who developed progressive mCPRC and bone metastases after receiving ≥1-line androgen receptor (AR)-targeted therapy but no known BRCA-1 or BRCA-2 variants or larger visceral disease.
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European Radiology: Deep learning makes breast MRI more "grounded"!
Time of Update: 2022-11-14
The performance of the model is evaluated by ROC curve analysis of independent test sets, and the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the high sensitivity threshold are calculated.
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August is exciting: "2022 Breast Tumor Elite Practice and Exchange Project - Jiangsu Station" is enthusiastically coming!
Time of Update: 2022-11-14
Speaker: Dr. Siying Zhou (The First Affiliated Hospital of Soochow University) Case 2 Sharing: Dr. Wu Haohao (Yancheng First People's Hospital)The patient, 39 years old, found left-sided breast cancer, multiple lymph node metastases in the left clavicle area and chest, liver metastases, lung metastases, and multiple bone metastases on June 2021.
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J Clin Oncol: Long-term efficacy of Margetuximab-cmkb in the treatment of metastatic HER2-positive breast cancer
Time of Update: 2022-11-14
The SOPHIA study, a randomized, open-label, pivotal Phase 3 clinical trial of Margetuximab in the treatment of breast cancer, showed that Margetuximab+ chemotherapy significantly reduced the risk of disease progression or death by 24% compared with trastuzumab + chemotherapy in patients with metastatic HER2-positive breast cancer who had previously received multiple anti-HER2 regimens.
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World J Urol: Predictor Survey of Prostate Cancer When MpMRI is Negative
Time of Update: 2022-11-14
Researchers from Germany recently published an article in World J Urol evaluating the predictors of prostate cancer (PCa) when mpMRI is negative.
biopsy can be avoided in selected patient populations (mpMRI negative) (higher age, prostate volume and free PSA levels, and lower PSA density) if adequate follow-up care is ensured.
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Gut: Don't smoke! Yu Jun's team at Chinese University of Hong Kong found that cigarette smoke can promote colorectal cancer
Time of Update: 2022-11-14
On April 6, 2022, Yu Jun's team at Chinese University of Hong Kong published a research paper entitled "Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites online" in Gut (IF=32), which studied azomethane-treated C57BL/6 mice 2 per day hours of exposure to cigarette smoke or clean air for 28 weeks.
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Prostate: What is the effect of initiating salvage radiotherapy at PSA≤0.5ng/ml on metastasis-free survival in patients with postoperative recurrent prostate cancer?
Time of Update: 2022-11-14
investigating the effect of prostate-specific antigen (PSA) levels during salvage radiotherapy on relapse-free survival (bRFS) and metastasis-free survival (MFS) in patients with biochemical relapseUsing prospective institutional tumor registry data, the researchers constructed univariate and multivariate-adjusted Cox proportional risk models to assess the association between treatment outcomes and clinical and pathologic prognostic features, including pre-SRT PSA, interval from prostatectomy to SRT, androgen deprivation therapy (ADT), and adverse pathologic features.
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J Clin Oncol: Long-term prognosis for pembrolizumab monotherapy for PD-L1-positive NSCLC
Time of Update: 2022-11-14
02885 KEYNOTE-042 is a phase III randomized trial with initial results showing that pembrolizumab monotherapy significantly prolongs overall survival (OS) in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with a previously untreated PD-L1 tumor proportion score (TPS) of ≥1% compared with platinum-based chemotherapy.
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European Radiology: How to noninvasively distinguish benign and malignant Vater ampullary stenosis?
Time of Update: 2022-11-14
This study shows that predictive nomograms using enhanced CT imaging results and clinical results can be used to distinguish benign and malignant Vater ampullary stenosis, which provides a reference for non-invasive and accurate clinical evaluation.
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Mediastinal lymphoma (HL, NHL) imaging findings
Time of Update: 2022-11-14
Mediastinal non-Hodgkin lymphoma (NHL)Mediastinal Hon-Hodgkin LymphomaOverview:A group of malignant solid tumors from B-cell, T-cell, NK cell lymphoid tissue:Image representation:Differential diagnosis:(Left) Primary mediastinal large B-cell NHL and superior vena cava syndrome (SVC syndrome), PA chest x-ray showing diffuse enlargement of the mediastinum on both sides with marginal lobes.
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European Radiology: The value of radiomic analysis in assessing treatment response and prognosis in patients with hypopharyngeal cancer
Time of Update: 2022-11-14
c ROC curve for rad scores in the training and validation cohortIn this study, a radiomics model based on the radiomic features of pre-treatment CT is proposed, which can be used to detect IC responses in patients with LACC.
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When genetic sequencing can save lives, how can it be slow?
Time of Update: 2022-11-14
The HUAWEI CLOUD AI Gene Platform based on AI and big data provides high-performance, reliable, and cost-effective gene sequencing computation, storage, analysis, and AI capability support, standardizing and executing the scientific research process, thereby helping to speed up gene sequencing, improve efficiency, and reduce costs.
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Endless learning, re-exhibition: 2022 breast tumor elite practice and exchange project - Guizhou Station, kicked off!
Time of Update: 2022-11-14
In order to promote the progress of standardized diagnosis and treatment of breast cancer and promote in-depth and extensive exchanges in the field of breast cancer, the "2022 Breast Tumor Elite Pract
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European Radiology: Radiographic, noninvasive grading diagnosis of mandibular squamous cell carcinoma
Time of Update: 2022-11-14
In A, the tumor is far away from the mandible canal (MC), while in B, the tumor appears to infiltrate the MCThis studyretrospectively included 24 patients with mandibular squamous cell carcinoma (SCC),eachof whom underwent MRI prior to surgery, including CS-3D-T1TFE and MDCT examinations.
