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Light chain (AL) amyloid degeneration first treatment! Johnson and Johnson Darzalex Faspro Apply for New Allergies: Hematological Remission Rate Up to 92%
Time of Update: 2020-09-26
Darzalex is the world's first CD38-mediated, soluble cellular antibody drug, the first FDA-approved monoclonal antibody drug to treat multiple myeloma (MM), its intravenous preparation (IV) was launched in 2015, has become the backbone of clinical treatment MM therapy, widely used in first-line, second-line, multi-line therapy.
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Effect of surgery on cognitive function in patients with glioma.
Time of Update: 2020-09-25
Conclusion This meta-analysis showed that glioma surgery had a positive beneficial effect on patients' overall attention, language, learning and memory, but had a negative impact on executive function, both immediately after surgery and during six months of follow-up.
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Cell Rep: Lack of oxygen is the cause of cancer metastasis! "Oxygen therapy" or the key to cancer treatment.
Time of Update: 2020-09-25
It is worth noting that the study also found that targeted inhibitory endosthort growth factor (VEGF) can lead to the contraction of primary tumors, but at the same time, it also increases the hypoxia environment within the tumor, inducing more circulating tumor cells (CTCs) cluster shedding and metastasis formation.
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ATG-010 (selinexor) completed the first recurring incurable external weekly T and NK/T cell lymphoma patients.
Time of Update: 2020-09-25
On September 14, Deqi Pharmaceuticals announced that the oral selective nuclear output inhibitor ATG-010 (selinexor) has completed its first phase I clinical trial (code name: TOUCH) in China for patients with recurring incurable external T-cell lymphoma (PTCL) and NK/T-cell lymphoma (NKTL).
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$21 billion! Gilead acquires Next Generation Antibody Drug Concedes (ADC) developer Immunomedics!
Time of Update: 2020-09-25
the deal will bring Gilead a pioneering Trup-2 targeted antibody drug, ADC's Trodelvy (ADC), which was approved by the FDA in April to treat adult patients with metastasis triple negative breast cancer (mTNBC) who have received at least two treatments for metastasis.
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The mechanism by which IDO1 inhibitors play a role in gliomas.
Time of Update: 2020-09-25
1-MT inhibits IFN-gamma-induced actin F-actin expression, IDO1 and TDO over-expression, as well as Kyn treatment can increase F-actin expression, knocking out TDO inhibits F-actin expression, indicating that IDO1/TDO-Kyn-AhR-AQP4 signaling path is playing an important role in regulating glioma cell migration and invasion.
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Positive anti-accumulation capsules included in the 2020 edition of The Clinical Practice Guide to Oncology Psychology in China
Time of Update: 2020-09-25
Professor Wang Liping of the First Affiliated Hospital of Zhengzhou University, Henan Province, and Professor Tang Lili, Director of the Rehabilitation Department of Peking University Cancer Hospital, said that there is a lot of evidence in the clinic that effective psychological social services can alleviate the symptoms and psychological pain of patients with malignant tumors, while improving the quality of life and even prolonging the survival time.
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$21 billion! Gilead's acquisition of Immunomedics will include "first-in-class" antibody consuming drugs into the pocket.
Time of Update: 2020-09-25
it is understood that detailed results of asCENT, a clinical trial on Trodelvy's treatment of late-stage mTNBC3, are expected to be presented at this year's virtual meeting of the European Society of Oncology (ESMO), in addition to data on Trodelvy's treatment of patients with HR-/HER2-breast cancer as a third-line therapy and other solid tumors such as bladder cancer in registered Phase 2 clinical trials.
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npj Precision Oncology: Amazing! The venom of small bees is of great use and can kill cancer cells 100% in in-body experiments.
Time of Update: 2020-09-24
Specifically, researchers at the University of Western Australia's Medical Research Centre tested the anti-cancer properties of 312 bees and bumblebee venoms in breast cancer and found that bee venom can completely destroy cancer cell membranes within 60 minutes, and that specific concentrations of bee venom can induce 100% of cancer cell deaths with little impact on normal cells.
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Nat Immun: Does PD-1 blocking therapy work? Japanese scientists have proposed a new indicator of efficacy.
Time of Update: 2020-09-24
study, the PD-1 expression balance between effective and regulatory T-cells (Treg) can predict the clinical efficacy of PD-1 blocking therapy.
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The 2020 China Lung Cancer Prevention and Control Summit Forum was held in Beijing to help improve the five-year survival rate of lung cancer.
Time of Update: 2020-09-24
On September 11, 2020, in response to the call for "Healthy China Action (2019-2030) Cancer Prevention and Control Action", the 2020 China Lung Cancer Prevention summit forum, hosted by the Beijing Be
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FDA approves Gawreto (pralsetinib) treatment for metastasis RET fusion positive for non-small cell lung cancer.
Time of Update: 2020-09-24
, a member of the Roche Group, announced today that the U.S. Food and Drug Administration (FDA) has approved Gawreto™ (pralsetinib) for the treatment of metastasis RET fusion positive non-small cell lung cancer (NSCLC) patients.
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Cell Death Dis: ASC regulates the stability of HIF-1 alpha to induce the metastasis of squamous cell carcinoma in the mouth.
Time of Update: 2020-09-24
the study revealed that HIF-1 alpha was involved in asC-induced tumor metastasis.
researchers identified 195 genes associated with cellular movement that were highly SAS_ASC in ASC-expressed cells.
further studies showed that the initiators of these 14 ASC-induced highly expressed genes all contained a binding base sequence of the transcriptional regulator HIF-1 alpha.
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Cell Death Dis:PLC? is critical to maintaining the function of AR signals in prostate cancer.
Time of Update: 2020-09-24
(phospholipidase C) was highly expressed in CaP samples, and that the high expression level was closely related to the activity of ar signal transduction path.
addition, a positive correlation between PLC and AR signal activity was also observed in CaP samples that were resistant to bicalutamide and in CaP cell models of AR antagonists (toner).
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BMJ: Study of tumor risk in people who accidentally lost weight.
Time of Update: 2020-09-24
Recently, researchers quantified the predicted value of unexpected weight loss (WL) for tumor diagnosis based on the patient's age, sex, smoking status, and clinical characteristics (symptoms, signs, and abnormal blood test results).
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"Is chemotherapy causing nausea and vomiting a small thing to endure?" ...... Did you step on these pits of chemotherapy?
Time of Update: 2020-09-24
professor Xiang Yang, director of the Center for Oncology and Gynecology and Obstetrics and Gynecology at the Chinese Academy of Medical Sciences, Concord Medical University of China, Beijing Concord Hospital and deputy director of the Department of Obstetrics and Gynecology, said in a recent interview that with the continuous development of drugs, there are now good ways to prevent nausea and vomiting (CINV) caused by chemotherapy.
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EClinical Medicine: Increased risk of inflammatory macular degeneration in patients with bone marrow-boosting tumors.
Time of Update: 2020-09-24
, color-under-the-eye photo photography was taken on all patients to assess the prevalence of glass warts (compared to three previous large population-based studies).
compared to three previous population-based studies, the incidence of glass warts in MPNs patients increased significantly, with risk ratios of 5.7, 6.0 and 7.0, respectively.
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Cell Death Dis: Radish seed extract Sulforaphene may be a new treatment for esophageal cancer.
Time of Update: 2020-09-24
SCD and CDH3 can promote the metastasis of esophageal cancer by activating the Wnt signaling pathway, while the last two genes are involved in the positive feedback loop of GED45B-MAP2K3-p38-p53, thereby inhibiting the growth of esophageal cancer.
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Cell Death Dis: Powerful herbal formula SH003 activates the autophagy cell death process for stomach cancer.
Time of Update: 2020-09-24
addition, these results show that in hypoxia, SH003-induced endocystic network stress response can regulate the autophagy cell death process induced by BNIP3 by inhibiting the STAT3-G9a path pathline.
, SH003 therapy may be an important cancer treatment strategy under hypoxia-mediated chemotherapy resistance.
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Nature: Scientists find key to 'stopping' cancer cells - TRIM37 or cell division 'inverter'
Time of Update: 2020-09-24
An article by scientists at Hopkins University, entitled Target TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer, kills certain human breast cancer cells by selectively attacking the core of the cell division mechanism, providing new inspiration for our search for drugs that destroy cancer cells without harming healthy cells.
