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Treatment of newly diagnosed glioblastoma in the elderly
Time of Update: 2020-11-01
study found: (1) effects of different treatments on overall survival rates: Highly determinative evidence suggests that CRT can extend overall lifetime (OS) compared to RT40 (HR=0.67; 95% CI, 0.56-0.80).
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Ang Chem Int Ed: Scientists have developed a new collaborative anti-cancer combination therapy that could hopefully target multiple types of cancer
Time of Update: 2020-11-01
However, some cancer cells develop resistance so that the drug does not enter the cancer cells or the cancer cells can quickly repair damaged DNA strands, and in order to enhance the effectiveness of the therapy, the researchers combined chemotherapy with photodynamic therapy to develop a combination of anticancer therapies, all of which can be wrapped in nanocapsules and transported to tumor cells.
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Astrogenic glial cells promote the proliferation of glioblastoma
Time of Update: 2020-11-01
survival analysis of TCGA GBM showed that patients with high astrogenic glial cell characteristic scores had significantly short survival periods (p-0.037).
analysis of multivariate survival using Cox proportional risk model showed that the high expression of bone membrane protein (POSTN) with ascental glial cell characteristic score was significantly correlated with shorter survival time (HR=1.37; 95% CI, 1.06-1.77; p=0.017).
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Science Sub-Journal: Using viral simulation drugs to help the immune system target and kill cunning cancer cells
Time of Update: 2020-10-31
OCT 23, 2020 /--- In a new study, researchers at the University of California, Los Angeles, found that a drug that activates the body's natural defense system like a virus may also make certain invisible melanomas visible to the immune system, making immunotherapy better targeting them.
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THE MRI shows that SVZ is infringing in combination with tumor genomics to judge the LGG prognostics
Time of Update: 2020-10-31
all patients were mrI-tested, and two neuroradiologists read MRI images to determine whether the tumor violated SVZ and measure the distance between the tumor and the edge of the lateral chamber membrane (Figure 1).
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How can scientists use artificial intelligence to improve the diagnosis and treatment of a variety of human diseases?
Time of Update: 2020-10-31
: New algorithms may use artificial intelligence to help manage doi:10.1038/s42255-020-0212-y In a recent study published in the international journal Nature Metabolism, scientists from institutions such as Oregon Health and Science University used artificial intelligence and automated monitoring to develop a new method that could help people with type 1 diabetes better manage their blood sugar levels.
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The treatment of glioblastoma by Gregorian can prolong survival
Time of Update: 2020-10-31
mRNA analysis found that high expression HIF1A, CTSK, SLC2A1, KLHL12, CDKN1A, CA12, WDR1, CD53 mRNA and low expression C were higher in the Rigoffini group than in the Lomostin group Patients with BR4, NIFK-AS1, RAB30-DT mRNA had significantly longer OS, with the medium OS in 10.6-20.8 months (Rigoffinist) and 5.4-8.4 months (Lomostin group) respectively.
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Clin Cancer Res: Thyroid hormone replacement therapy makes breast cancer patients have a poor prognostication.
Time of Update: 2020-10-30
researchers have conducted an observational study to verify that THRT can produce harmful clinical effects through mechanisms such as hormone interactions, nucleo-subject intersections, and high-risk BC gene uptence.
study looked at BC patients with lymph nodes negative (LN-) (n=820 and n=160) to test the interaction between THRT and clinical, histological, prognostic and therapeutic variables.
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Nat Commun:5-FU activates the WNT/β-catenin path, promoting the dryness of colorectal cancer.
Time of Update: 2020-10-30
The results of these studies suggest that p53 is a key medium for 5-FU to induce CSC activation through the WNT/β-catenin signaling pathrapy, and highlight the significance of WNT inhibitors and 5-FU combination therapy, which is a compelling treatment strategy that can improve the current adverse outcomes of 5-FU-based therapies in CRC patients.
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Take stock: A selection of Blod research on October 22, 2020.
Time of Update: 2020-10-30
The cost-effective https://doi.org/10.1182/blood.2020004922ALLIANCE trial in patients with CLL found that the first-line treatment significantly extended the progression of patients with lysotin monoa
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Science Advances: An efficient detection strategy for common brain tumors in children - ctDNA fluid biopsies.
Time of Update: 2020-10-30
the cytosine modification of the cerebrospinal fluid ctDNA is ultimately consistent with the high degree of in-place MB tumor detection, this study will lead to the development of a biomarker kit that clinicians will be able to use to monitor patients with childhood brain tumors.
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Lancet Oncol: 100,000 people, 10 years of follow-up! Is the incidence of stomach cancer related to genetic and healthy lifestyle geometry?
Time of Update: 2020-10-30
China has one of the highest incidences of stomach cancer, which accounts for more than 40% of all cases worldwide. In October 2020, a team of shen Hongbing academicians from Nanjing Medical Universi
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JCO:HER2 dual targeted therapy significantly improves prognostication in breast cancer patients.
Time of Update: 2020-10-30
In the CALGB 40601 trial, 350 untreated stage II-III HER2-positive breast cancer patients were randomly assigned to three groups to receive treatment of yew alcohol-combined cytoproquine-lapatini (THL), yew alcohol combined monoantigen (TH) or yew alcohol-combined rapatinib (TL).
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Phase I/II clinical trials for the treatment of advanced pancreatic cancer at GC4419: positive data have been obtained.
Time of Update: 2020-10-30
If left untreated, elevated superoxides can damage non-cancerous tissue and lead to debilitating side effects, including oral mucositis (OM), which may limit the anti-tumor efficacy of radiation therapy.
, President and CEO of Galera, said: "There are limited treatment options for pancreatic cancer patients.
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METTL3 inhibitor sTC-15 treats acute myeloid leukemia.
Time of Update: 2020-10-30
STC-15 is an oral small molecule METTL3 inhibitor used to treat acute myeloid leukemia and other solid and blood cancers.
The sTC-15 is an efficient and selective METTL3 inhibitor, and patients with acute myeloid leukemia will be included in the initial clinical trials," said Keith Blundy, CEO of STORM Therapeutics.
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Tozhu single resistance china has been approved for the treatment of car-T therapy caused by cytokine storms.
Time of Update: 2020-10-30
The approval of this free clinical trial for the treatment of CRS allergy is based on the clinical trial data of CAR-T cell therapy for blood system diseases provided by two CAR-T companies worldwide, which effectively evaluates the efficacy of toad monotherapy CRS.
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Br J Cancer: Pre-radiation neutral granulocyte lymphocyte ratio (NLR): prognostic indicator for patients with oral and pharynx cancer.
Time of Update: 2020-10-29
based on a strated analysis of tumor (T) stages and the overall survival rate of NLR, the results reveal that pre-radiation NLR is an independent prognostic factor in patients with oral and pharynx cancer, independent of the status of HPV.
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Nature: Two in the same period! From basic research to drug development, Li Ming's team invented "Cancer Environmental Immunotherapy"
Time of Update: 2020-10-29
the results, published in the first Nature paper, the authors showed that blocking the TGF-β signaling path on CD4 plus T cells activates a powerful wound healing response that prevents cancer cells from growing.
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Cell Death Dis: High expression levels of DHODH-β-catenin promote the development of esophageal squamous cell carcinoma.
Time of Update: 2020-10-29
DHODH promotes tumor development in general, the results reveal the key role of the β-catenin signal transduction path of DHODH mediated, suggesting that DHODH may act as a versatile switch that can catalyz the metabolism of sorine and regulate tumor-related signaling path paths in ESCC.
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Br J Cancer: APC deficiency induces the Warburg effect of colorectal cancer cells by mediating the Wnt/β-catenin/PKM2 path.
Time of Update: 2020-10-29
the study sheds light on the key link between the Warburg effect and the abnormally activated Wnt/β-catenin signal transductive path, particularly in colorectal cancer (CRC), where APC (adenoma-related gene associated with colon pliosarcoma) is defunct.
