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Cancers: The latest mechanism of action for cancer drugs
Time of Update: 2021-02-15
" these small differences are directed by PD-1 molecules into killer cells and have the desired effect, i.e., although the drug binds to the subject, it does not activate the subject as the natural surface molecule PD-L1 does.
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Nat Biomed Engine: Scientists have developed new mathematical methods that could help predict the effectiveness of immunotherapy in treating cancer
Time of Update: 2021-02-15
researchers found that the two model-derived measures were able to quantify the presence and health of the immune system inside the tumor, while the mortality rate of cancer cells caused by immunotherapy-activated immune cell sniping could be combined into a single measurement highly related to the long-term tumor burden, providing the tumor The researchers then studied an additional 177 patients who received one of the common checkpoint inhibitors immunotherapy (anti-CTLA4 or anti-PD1/PDL1 immunotherapy) to confirm the results.
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PNAS: Scientists reveal molecular therms for overcoming leukemia resistance
Time of Update: 2021-02-15
Finally, from a therapeutic perspective, this paper suggests that PON2 enzyme activity may be used to selectively kill B-ALL cells, targeting PON2 or promising to help develop new therapeutic interventions to overcome resistance to B-cell acute lymphoblastic leukemia, the researchers said.
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PNAS: Uncovering the key role of CXCR4 subjects in cancer cells is expected to help develop individualized therapies for multiple cancers
Time of Update: 2021-02-15
February 3, 2021 // -- In a recent study published in the international journal PNAS, scientists from institutions such as the Max del Bruck Center for Molecular Medicine in Germany revealed the key r
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Nat Genet: The malfunction of the genome structure may induce the occurrence of B cell malignant tumors!
Time of Update: 2021-02-15
4, 2021 // -- In a recent study published in the international journal Nature Genetics, scientists from Columbia University's Irvine Medical Center and others found that errors in chromosome arrangement in B cells that produce antibodies appear to play a key role in the development of B-cell-related blood cancers.
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Clinical and imaging characteristics of atypical IDH mutant gliomas
Time of Update: 2021-02-15
Studies such as Poetsch have found that atypical IDH mutant gliomas have obvious imaging and histological characteristics and may be associated with genetic susceptivity in tumor development.
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Comparison of the two surgical methods of glioblastoma in the temporal lobe
Time of Update: 2021-02-14
Mattias Schneider of Neurosurgery at the University Hospital of Bonn, Germany, and others compared the safety indicators associated with standard surgical removal of glioblastoma of the temporal lobe and excision of the front temporal lobe, and found no significant difference in the effectiveness of the two surgical methods.
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Nature: Scientists reveal new molecular mechanisms that regulate the anti-tumor activity of immune cells!
Time of Update: 2021-02-14
Subir Biswas, a researcher, said the results of this study show that the use of immunotherapy may enhance the coordinated response of the body's B-cell nuclear T-cells against ovarian cancer, which is also a immunogenic disease that is resistant to checkpoint inhibitors, which often show better disease treatment.
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Blood: Why does CAR-T cell therapy fail in the treatment of some patients with lymphoma?
Time of Update: 2021-02-13
February 5, 2021 // -- Chimeric antigen-treated T-cell therapy (CAR-T-cell therapy) is a major map for the treatment of a variety of blood cancer therapies, such as acute lymphoblastic leukemia and di
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Cancer Immunol Immunother: Tumor Mutation Score (TMS) replaces Tumor Mutation Load (TMB) to predict the response of NSCLC patients to ICI treatment?
Time of Update: 2021-02-13
the predictive sensitivity of TMS18, TMB, and PD-L1 expressions, TMS18 is more effective than TMB in predicting the response of NSCLC patients to ICI treatment.
combined with TMS18 and PD-L1 may be more accurate in predicting the efficacy of ICI treatment in NSCLC patients.
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JAHA: Incidence, predictive indicators and mortality of liver cancer after Fontan surgery
Time of Update: 2021-02-13
shows that 30 years after Fontan surgery, the incidence of LC increased rapidly, and liver fibrosis index and AFP can be used as predictive indicators of new LC.
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Nat Commun: Multi-multi-dimensionalization of liver cells induces the occurrence of precancer lesions of hepatocellular carcinoma
Time of Update: 2021-02-13
further studies have shown that the increase in the expression level of the Aurkb gene plays a key role in promoting ultra-multiplying of cells.
, the results reveal a close molecular link between hepatocellular pathological polyhedrations and HCC cell transformation in the CL region.
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Hepatol Int: An individualized model that predicts mortality in liver cancer patients within 6 months of surgery!
Time of Update: 2021-02-13
of the model, the researchers developed an easy-to-use online predictive calculator that can screen patients with a high risk of death within six months of surgery for liver cancer.
online calculator may help guide surgical decisions to avoid unnecessary surgery for liver cancer patients who do not benefit from the operation.
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Nat Commun: Genome-wide association studies identify dangerous gene constellations for chronic lymphocytic leukemia
Time of Update: 2021-02-13
All in all, the results of the study reveal that rs736456 and rs3778076 are prognostic indicators of CLL, and that the results also indicate that the development of the disease is determined by inherent genetic mutations and known somtic cell drivers.
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Nature review: The incidence of fatty liver-related liver cancer is on the rise, affecting 1/4 of the world's population!
Time of Update: 2021-02-13
Generally, NAFLD is thought to be associated with obesity, but a systematic evaluation and meta-analysis published last May in Lancet's lancet-gastroenterology and hepatology found that 40 percent of patients with fatty liver disease are not fat and have a lot of co-merger.
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It's like a new life! 22-year-old man successfully changed his face and hands, half a year no rejection reaction!
Time of Update: 2021-02-13
To get back to normal life, DiMio underwent a 24-hour operation at New York University's Langone Medical Center that involved a number of delicate operations that involved connecting blood vessels, nerves, tendons, and eventually managed to replace the entire face and hands.
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Science Wins, Total Cancer - The world's first CDK4/6 inhibitor continues to respond to World Cancer Day to help Chinese patients fight advanced breast cancer
Time of Update: 2021-02-13
Every year on February 4th, World Cancer Day is established by the International Alliance against Cancer (UICC) and the World Health Organization (WHO) to promote cancer prevention and treatment worldwide, to raise the level of early diagnosis of cancer and reduce the incidence of cancer, and this year's theme is "Caring for Patients, Working Together against Cancer (I am and I will)".
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Nature: Breakthrough! Reveal the molecular factors that genetic and environmental factors "collusively" promote pancreatic cancer!
Time of Update: 2021-02-13
researcher Alonso Curbelo said: 'We were able to identify at the molecular level the difference between the normal repair process and the cancer starting repair process, and we also found in damaged KRAS mutant cells that the way chromatin is organized may change uniquely.' these changes, different genes are turned on or off, giving cells the characteristics of early cancer.
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WHO estimates that new cancer cases will increase by nearly 50% in 2040 compared to 2020
Time of Update: 2021-02-12
The Number of new cancer cases is expected to increase significantly in the coming decades, with the number of new cases worldwide expected to increase by nearly 50% by 2040 compared with 2020, with low- and middle-income countries seeing the largest increase, the World Health Organization said.
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Nat Commun: The esodiol dosing trial revealed the relationship between progesterone-like and endocrine therapy responses in breast cancer patients
Time of Update: 2021-02-12
, the results show that changes in tumor FFNP intake after esodiol therapy can highly predict the response of women with ER-plus breast cancer to ET treatment.
