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Gynecol Oncol: The therapeutic effect of Nelatinib in patients with HER2 mutation and metastatic cervical cancer
Time of Update: 2021-04-22
The study enrolled 16 patients with HER2-mutated, persistent, metastatic/recurrent cervical cancer who had advanced or advanced disease after platinum treatment and received oral neratinib 240 mg/day and loperi in the first cycle.
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Brit J Cancer: Body mass index and absolute lymphocyte count can predict disease-free survival of breast cancer patients
Time of Update: 2021-04-22
Researchers retrospectively identified 1225 patients with primary invasive breast cancer and 35,991 healthy women, and used a multivariate Cox proportional hazard model to evaluate factors such as BMI and complete blood count related to disease-free survival (DFS).
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Why can I live with cancer for more than ten years?
Time of Update: 2021-04-22
On the morning of April 14th, the Second People’s Hospital of Guangdong Province (hereinafter referred to as "the Second Provincial Hospital") launched the 2021 National Cancer Prevention Week series of activities and medical humanities improvement plan, so that everyone can enter the hospital with warmth, and the tumor ward will no longer be cold.
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NEJM: HSV-1G207 oncolytic virus therapy for high-grade glioma in children
Time of Update: 2021-04-22
At present, clinically, the 3-year event-free survival rate of patients with new-onset malignant high-grade glioma who received standard radiotherapy and chemotherapy is only 11%-22%, and the average life expectancy of relapsed patients is only 5.
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Eur Radiol: The ability of the human eye to detect changes in the size of lung nodules
Time of Update: 2021-04-22
The standard baseline nodule diameter, relative volume difference, and nodule type are statistically significant factors that affect the accuracy of radiologists (p <0.
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Cell Stem Cell: The first patient-derived cervical cancer organoid model, providing new methods for cervical cancer research
Time of Update: 2021-04-22
On April 13, 2021, the Hans Clevers team from Utrecht University in the Netherlands published a research paper titled Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer in the Cell Stem Cell journal.
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Hepatology: Affects 1/4 of adults-the risk of fatty liver is far more than liver cancer!
Time of Update: 2021-04-22
Diabetes compared with the control group, patients with these different stages of NAFLD are increased risk of hepatocellular carcinoma 61%, 145% and 395% correlation.
Compared with the control group, NAFLD patients at the above different stages are associated with an increased risk of hepatocellular carcinoma by 61%, 145%, and 395%, respectively.
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Lancet Oncol: The susceptible genetic variation of cervical precancerous lesions and invasive cervical cancer!
Time of Update: 2021-04-22
Smoking at first pregnancy, older age and more sex partners , all contribute to the risk of cervical cancerIn summary, the results of this study provide new evidence for the genetic susceptibility of cervical cancer, especially PAX8, CLPTM1L and HLA genes, suggesting that the interference of apoptosis and immune function pathways may play an important role in the occurrence of cervical cancer .
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Eur Radiol: For predicting the survival of HCC patients, imaging performance may be more important
Time of Update: 2021-04-22
Manage blood vessels Recently, a study published in the journal European Radiology evaluated the relationship between tumor ADC values and edge conditions and overall survival (OS) and transplant-free survival (TFS) of HCC patients, and evaluated the pairing of these two parameters including BCLC and The added value of the established clinical staging system including CLIP.
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A prospective multi-center clinical study on the differential diagnosis of benign and malignant pulmonary nodules based on multi-omics | Live Preview
Time of Update: 2021-04-22
MISSION ( M ULTI-OM the I cs CLA SSI Fier for Pulm O nary N odules) program by the Shanghai Pulmonary Hospital to participate in a number of other 10 hospitals nationwide , initiated by Taylor bio-led, designed to take advantage of multi-omics technologies ( Metabolome, proteome, epigenetics, imaging group), a prospective multi-center clinical research project for the differential diagnosis of benign and malignant pulmonary nodules in patients with small lung nodules (≤3cm) on medical images .
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International Cancer Research Organization IARC: HPV vaccination for girls of school age in my country will reduce more than 90% of cervical cancer patients!
Time of Update: 2021-04-22
LancetCombining the age-specific incidence rate of GLOBOCAN in 2018 and the age-specific mortality rate predicted by the United Nations population to estimate the expected number of cervical cancer cases for girls born between 2005 and 2014 without vaccinations.
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Focus on tumor prevention and control, experts call for: early screening, early diagnosis and early treatment of liver cancer should be concerned by the whole society
Time of Update: 2021-04-22
On April 17, sponsored by Eastern Hepatobiliary Surgery Hospital of Naval Military Medical University/National Liver Cancer Science Center, co-organized by Fujian Cancer Hospital and Mengchao Hepatobiliary Hospital of Fujian Medical University, undertook by Herui Gene, supported by People’s Daily Health Client and Chief Media of Health Times The National Multi-center Prospective Liver Cancer Very Early Warning Screening Project (PreCar) Progress Meeting and the First Tumor Early Diagnosis and Treatment Precision Prevention and Control Summit Forum was held in Fuzhou.
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Am J Med Sci: Preoperative vitamin D supplementation can reduce the incidence of postoperative hypocalcemia in patients with total thyroidectomy
Time of Update: 2021-04-22
Considering the role of 25- hydroxyvitamin D (25(OH)D) in hemostatic calcium, researchers conducted a randomized clinical trial to evaluate the effect of preoperative vitamin D supplementation on the incidence of hypocalcemia in patients undergoing thyroidectomy Impact, the research results have been published in Am J Med Sci. Vascular Vitamin DThe study included 100 patients with moderate or severe vitamin D deficiency who planned to undergo total thyroidectomy.
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Eur Radiol: The value of CTA for prostate artery embolization
Time of Update: 2021-04-22
Intraoperative navigational vessel angle, prostate volume, prostate artery (PA) diameter, PA origin, aortic atherosclerosis, iliac vessel curvature, and baseline demographic data and outcome variables (perspective time, air kerma (AK)) , Dose area products (DAP)), the number of cone beam CTs (CBCTs)) and whether bilateral embolization is possible (technically successful).
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2021 SGO | Are genomically unstable tumors more sensitive to immune checkpoint inhibitors?
Time of Update: 2021-04-21
The IMagyn050 study was stratified according to the expression status of BRCA1/2, HRD and PD-L1, and explored the efficacy of immune checkpoint inhibitors in patients with genomically unstable tumors.
Regardless of BRCA1/2 mutation or HRD status, CPB+atelizumab cannot improve PFS.
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ELCC2021: These advances in lung cancer treatment, you need to know
Time of Update: 2021-04-21
The KEYNOTE-407 study is a multicenter, randomized, double-blind, placebo-controlled phase III clinical study, which aims to evaluate pembrolizumab or placebo combined with carboplatin and paclitaxel/albumin paclitaxel for stage IV squamous Efficacy and safety of first-line treatment for NSCLC patients.
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The world's first first-line treatment of esophageal cancer PD-1 was born!
Time of Update: 2021-04-21
The results of the interim analysis of KEYNOTE-590 showed that in the first-line treatment of patients with locally advanced and metastatic esophageal cancer, pembrolizumab combined with chemotherapy compared with conventional chemotherapy has brought benefits to the entire population, significantly improved overall survival, and reduced The risk of death from disease is 27%, and the safety is controllable.
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Science: Major development of CAR-T cells that recognize the expression level of protein antigens on the surface of cancer cells, which is expected to be used in the treatment of solid tumors
Time of Update: 2021-04-21
Anna Mäkelä, a postdoctoral researcher in the Saksela laboratory, is coordinating a project funded by the Finnish Academy of Sciences to study the application of CAR-T cell therapy on various cancer types and their surface structures.
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Significantly prolongs the lives of prostate cancer patients, Novartis targeted radiotherapy reaches the phase 3 clinical endpoint
Time of Update: 2021-04-21
▎Editor of WuXi AppTec's content team On March 23, Novartis announced that its potential "first-in-class" targeted radioligand therapy (RLT) 177Lu-PSMA-617 is in the treatment of stage 3 of patients with advanced prostate cancer.
Retrieved March 23, 2021, from novartis-announces-positive-result-phase-iii-study-radioligand-therapy-177lu-psma-617-patients-advanced-prostate-cancer[2] Novartis Oncology Pipeline Update.
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The first domestic RET inhibitor! CStone's Pratinib approved
Time of Update: 2021-04-21
According to the announcement by the National Medical Products Administration (NMPA) on March 23, CStone’s RET inhibitor pralsetinib’s new drug listing application review and approval status has been updated to "Approval completed-pending certification", and the indication is Have previously received platinum-containing chemotherapy for transfection rearrangement (RET) fusion-positive locally advanced or metastatic non-small cell lung cancer (NSCLC).
