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Zhou Zheng and Xu Dong revealed a new mechanism for EBV to inhibit host DNA damage response

 Last Update: 2022-09-14
 Source: Internet
 Author: User

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DNA carries the cells' genetic information, and its stable transmission and precise replication are essential

Epstein-Barr virus is a γ herpes virus with a double-stranded DNA genome that infects about 90% of the world's population and is associated with multiple malignant tumors

Proceedings of the National Academy of Sciences of the United States of America, September 6, 2022 Published online the research paper "Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses"

The researchers first analyzed the high-precision crystal structure of the BKRF4 histone binding element (HBD) and the human H2A-H2B dimer complex, and at the same time used nuclear magnetic resonance (NMR), isothermal calorimetric titration (ITC), pull-down and other methods to prove that BKRF4-HBD interacted

In summary, this study reveals the molecular mechanism

Figure BRKF4 regulates host nucleosome assembly and inhibits host DNA damage response

Zhou Zheng, researcher of the Institute of Biophysics, Xu Dongyi, researcher of Peking University, and Shan Shan, associate researcher of the Institute of Biophysics, are the co-corresponding authors

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(Contributed by: Zhou Zheng Research Group)

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