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Recently, a research paper titled The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis jointly completed by Zhou Ming's research group of the Institute of Botany and Julie Law 's research group of the Salk Institute of Biology in the United States was published in Nature Communications .
A mature individual has the same set of genome, but can develop into different types of cells, tissues and organs, epigenetic modification patterns are thought to play an important role
.
DNA methylation is a type of epigenetic modification that occurs on the 5th carbon atom of cytosine and can be stably inherited.
It is widely present in animal and plant genomes
Plant de novo DNA methylation (de novo methylation) by RNA -directed DNA methylation pathway (RNA-directed DNA methylation, RdDM ) established
.
Ming Zhou discovered that the four -member chromatin remodeling factor gene family CLASSY (CLSY1-CLSY4) plays an important role in regulating the de novo establishment of DNA methylation
This study further found that four CLSY genes exhibited distinct tissue expression specificity in Arabidopsis ( Fig.
1.
Figure 1.
Expression of CLSY1-4 is tissue-specific
Using multi-omics methods such as smRNAseq , RNAseq and BSseq , the researchers further revealed the differences in DNA methylation patterns among different tissues including Arabidopsis inflorescence, ovule, first and second true leaves and rosette leaves ( Figure 2.
a)
Figure 2.
CLSY proteins regulate tissue-specific DNA methylation patterns
This work sheds light on the genetic basis of the CLSY family of chromatin remodelers regulating the differences in DNA methylation patterns among different tissues in plants
.
Given the conservation of DNA methylation in animals and plants, this work opens up the possibility to further utilize epigenetic mechanisms to improve precision breeding and precision medicine in crops
The work was jointly completed by the School of Life Sciences of Zhejiang University and the Salk Institute of Biology in the United States .
Researcher Zhou Ming from the School of Life Sciences, Zhejiang University is the first author, and his work has been supported by Zhejiang University and the 111 Program of Central Universities .
Paper link: https://
