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Zhou Jing's team revealed how the matrix geometry of the vascular wall affects the function of smooth muscle cells

 Last Update: 2022-10-03
 Source: Internet
 Author: User

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On September 14, 2022, Zhou Jing's research group in the Department of Physiology and Pathophysiology of the School of Basic Medicine, Peking University Medical College published a report online in the journal Advanced Science titled Geometric constraints regulate energy metabolism and cellular contractility in vascular smooth muscle cells by Coordinating mitochondrial DNA methylation research paper.

In the previous work of this research group, it was found that DNMT1 in VSMC underwent nucleo-to-mitochondrial redistribution under the stimulation of platelet-derived growth factor (PDGF), and that mitochondrially localized DNMT1 could bind to the D-loop of mitochondrial DNA (mtDNA) and eventually lead to mtDNA transcription inhibition [3

Zhou Jing's research group is committed to the development and application of various in vivo and ex vivo model systems that simulate non-sibling physical microenvironments (such as blood flow shear and mechanical stretching, matrix stiffness and topology, etc.

Original link: https://onlinelibrary.

References:

【1】Suzuki, M.

【2】Odero-Marah, V.

【3】Liu, Y.

(School of Basic Medicine, Peking University)

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