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Zhong Yi's research group from Shanghai Institute of Immunotherapy Innovation published online research results, in order to explore high-efficiency immunity...

 Last Update: 2022-01-07
 Source: Internet
 Author: User

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Recently, Zhong Yi’s research group from Shanghai Institute of Immunotherapy Innovation, Renji Hospital, Shanghai Jiaotong University School of Medicine published an online publication titled "The Hierarchical Regulation and Effect of Multi-transcription Factor Family " in Nature Immunology .

This work elaborated on the internal regulation characteristics of the classic process of immune cells differentiate from the silent state into effector cells, which not only helps to strengthen researchers' understanding of immune cell biology, but also has a lasting effect on the exploration of high-efficiency immunotherapy methods and designs.

For a long time, people have had a relatively complete understanding of the functional changes that accompany the process of differentiation of immune cells into effector cells after activation

Researcher Zhong Yi conducted a series of studies using the natural genetic variation widely distributed on the chromosomes of hybrid mice, and successfully quantified the strength of transcription factors shaping chromatin structure in specific cells, and clarified that different transcription factor families regulate T cell functions The inner synergy of the above, and the dynamic changes of this relationship in different stages of differentiation

Zhong Yi from the Shanghai Institute of Immunotherapy Innovation is the first author of the paper.

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