Zhong Nanshan team: the median incubation period of the virus was 3 days, and more than 50% of the patients had no fever symptoms when they were treated

Author: Wang Fang According to statistics of China Health and Health Commission, as of 24:00 on February 10, 31 provinces (autonomous regions, municipalities directly under the central government) and Xinjiang production and Construction Corps reported 37626 confirmed cases (7333 severe cases), 3996 cured and discharged cases (1 Zhejiang nuclear reduction), 1016 dead cases and 42638 confirmed cases (12 Zhejiang nuclear reduction and 1 Jiangxi nuclear increase), There are 21675 suspected cases The total number of close contacts was 428438, and 187728 were still under medical observation On February 9, the latest report of 2019-ncov, led by Zhong Nanshan, a senior expert group leader of the National Health Commission and academician of the Chinese Academy of engineering, was published on the preprint website medrxiv (none of the papers on the website have been peer reviewed), which provides a new reference for people to understand the characteristics of the virus and the prevention and control work Novel coronavirus pneumonia is the largest novel coronavirus pneumonia in the world The latest report of https://doi.org/10.1101/2020.02.06.20020974 covers the data of 1099 new crown pneumonia patients diagnosed in 552 hospitals in 31 provinces and municipalities in China as of January 29th Among these patients, 2.09% were medical staff, 1.18% had contact with wild animals, 31.30% had recently been to Wuhan, 71.80% had contact with Wuhan people, 483 (43.95%) local residents in Wuhan, 26.0% had neither been to Wuhan nor had contact with Wuhan people This proves once again that human to human communication is the main way to spread 2019 ncov According to the study, the median age of the patients was 47 years old, 41.9% of them were women, 2019-ncov was diagnosed in the whole age group, and 0.9% of the patients were under 15 years old The median incubation period was 3.0 days (range 0 to 24.0) A quarter of all confirmed patients have at least one underlying disease (hypertension, COPD) In terms of clinical characteristics, the most common symptoms were fever (87.9%) and cough (67.7%), while diarrhea (3.7%) and vomiting (5%) were rare However, it should be noted that only 43.8% of the patients had fever at first and 87.9% had fever after hospitalization This suggests that such patients may be missed if the criteria for diagnosis are mainly focused on fever testing Pneumonia was not an inevitable disease 840 patients with lymphocytopenia in 82.1% of the patients had chest CT examination at the time of admission, 76.4% of them showed pneumonia The common CT images were ground glass shadow (50.0%) and bilateral patchy shadow (46.0%) Among 926 non critical cases, 221 (23.87%) had no abnormal CT image, and in 173 critical cases, 9 (5.2%) had no abnormal CT image These cases were finally confirmed by general symptoms and positive viral nucleic acid test Among all patients, 82.1% had lymphocytopenia and 36.2% had thrombocytopenia Overall, 33.7% of patients had leukopenia In most patients, the level of C-reactive protein was increased, while the level of alanine aminotransferase, aspartate aminotransferase, creatine kinase and D-dimer were not During hospitalization, 79.1% of the patients had pneumonia In these patients, 38.0% received oxygen treatment, 6.1% received mechanical ventilation, 57.5% received intravenous antibiotic treatment, and 35.8% received oseltamivir, an anti influenza drug The most common complications during hospitalization were pneumonia (79.1%), ARDS (3.37%) and shock (1.00%) The incidence of complications in severe patients was significantly higher than that in non severe patients (94.8% vs 72.2%, P < 0.001) In clinical treatment, 5.00% of patients entered ICU, 2.18% needed invasive ventilation, and 1.36% died Compared with SARS CoV and mers CoV, the mortality of 2019-ncov is lower At the end of the report, it is mentioned that the pollutant transmission may play a role in the rapid spread of 2019 ncov, so we need to consider the transmission of gastrointestinal secretion At the same time, researchers need to make continuous efforts to explore an effective treatment Reference: [1] clinical characteristics of 2019 new coronavirus infection in China