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Zhejiang University and Shanghai Institute of Pharmacy jointly published a Nature article: Demystifying the mechanism of glycoprotein hormones

 Last Update: 2021-09-30
 Source: Internet
 Author: User

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On September 22, 2021, the Xu Huaqiang/Jiang Yi team of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and Zhang Yan's team from Zhejiang University, published the latest research results "Structures of full-length glycoprotein hormone receptor signaling complexes" in Nature for the first time The glycoprotein hormone GPCR, namely, the four structures of the full-length luteinizing hormone/choriogonadotropin receptor (LHCGR) in the inactive state and multiple activated states are analyzed
.

This work revealed the molecular mechanism of chorionic gonadotropin (CG) recognition of LHCGR, and revealed the detailed mode of interaction between the small molecule compound Org43553 and the receptor LHCGR in phase 1 clinical trials; identified glycoprotein hormones that selectively bind to LHCGR and follicle stimulation The key amino acid residues of the follicle-stimulating hormone (FSH) receptor; the "Push and Pull" model of the receptor activated by the hormone ligand is proposed

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