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Zhao Bingqiao's team revealed that the small molecule drug MLN4924 improves neurovascular injury in stroke

 Last Update: 2022-03-07
 Source: Internet
 Author: User

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Recently, Prof.
Zhao Bingqiao's team from Fudan University's Institute of Brain Science/State Key Laboratory of Medical Neurobiology published a study titled "The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice" online in PNAS, the journal of the National Academy of Sciences.
The paper reveals the important role of the small molecule drug "MLN4924" in regulating neurovascular damage in stroke
.

Stroke, also known as "cerebral apoplexy", is the leading cause of death and disability among adults in China
.

The NEDD8 activating enzyme inhibitor "MLN4924" is a small molecule anticancer drug developed in recent years

This research was supported by the National Natural Science Foundation of China and the Key R&D Program of the Ministry of Science and Technology
.

Yu Huilin, Luo Haiyu, Chang Luping, and Wang Shisheng of West China Hospital of Sichuan University are the co-first authors of the paper; Professor Zhao Bingqiao of Fudan University, Researcher Fan Wenying and Associate Researcher Yang Hao of West China Hospital are the co-corresponding authors of the paper

Figure: Stroke-induced abnormal activation of the ubiquitin-like protein NEDD8 in neutrophils inside and outside the blood vessels

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PNAS: Zhao Bingqiao's team from Fudan University revealed that the small molecule drug MLN4924 improves neurovascular injury in stroke

03-07

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Zhao Bingqiao's team revealed that the small molecule drug MLN4924 improves neurovascular injury in stroke

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PNAS: Zhao Bingqiao's team from Fudan University revealed that the small molecule drug MLN4924 improves neurovascular injury in stroke