 Home > Biochemistry News > Biotechnology News > Yin Yuxin's team discovered a novel inter-organ long-distance communication mechanism: lung tissue extracellular vesicles regulate the chemotactic recruitment of bone marrow neutrophils in response to the invasion of pathogenic microorganisms

Yin Yuxin's team discovered a novel inter-organ long-distance communication mechanism: lung tissue extracellular vesicles regulate the chemotactic recruitment of bone marrow neutrophils in response to the invasion of pathogenic microorganisms

 Last Update: 2022-08-12
 Source: Internet
 Author: User

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On May 20 , 2022, Professor Yin Yuxin's team from Peking University School of Basic Medicine published a research paper titled "E xtracellularvesiclesfromlungtissuedrive bone marrow neutrophil recruitment in inflammation" in the Journal of Extracellular Vesicle.

EVs have been recognized in recent years as biomarkers for many diseases and as carriers of long-distance communication between cell.

The lung is an important respiratory hematopoietic org.

To solve the above problems, Yin Yuxin's team successfully established an efficient method to collect high-quality EVs from human and mouse normal lung tissue.

Further studies confirmed the presence of dsDNA insideand outside the membranes of lung EV.

Figure: Schematic diagram of the regulation of bone marrow neutrophil chemotaxis by lung EVs

In conclusion , this study established a high-quality separation and purification system for lung tissue EVs , which can accurately delineate their molecular composition and be used to study their distal regulatory functions in viv.

Liu Bowen, a doctoral student at Peking University School of Basic Medicine , and Jin Yuan, a postdoctoral fellow at Peking University School of Basic Medicine are the co-first authors of the paper, and Professor Yin Yuxin from the Institute of Systems Biomedicine, Peking University School of Basic Medicine is the corresponding auth.

Original link: https://d.

(Peking University School of Basic Medicine)

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