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Diabetes affects more than 400 million people worldwide and is a huge public health burden
The ubiquitin-proteasome-dependent protein degradation process is the main pathway for regulating intracellular protein levels
On June 7, 2022, a team from the Joint Center for Life Sciences, Professor Yin Yuxin's team from Peking University, and Professor Song Yongfeng's team from the Provincial Hospital Affiliated to Shandong First Medical University published a research titled Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses in Cell Metabolism The paper reveals a new mechanism by which the deubiquitinase system senses metabolic signals such as glucose and fatty acids and regulates energy metabolism
The research team found a diabetic family with features similar to juvenile-onset diabetes mellitus (MODY), but genome whole-exome sequencing did not detect a known causative gene mutation associated with MODY, suggesting that the family may be caused by a new disease.
The experimental study found that OTUD3 c.
In conclusion, this study found a new key pathogenic gene OTUD3 related to obesity and diabetes, and revealed a new energy metabolism regulation mechanism related to the function of OTUD3 protein, providing potential therapeutic targets for obesity and diabetes.
Postdoctoral fellow at Peking University School of Basic Medicine/Dr.
Original link: https://doi.
