Xu Jianqing's team and collaborator "Nature Immunology" reveal a new mechanism for virus-specific CD4+ T cell immune memory maintenance

 Immune memory is a hallmark feature of adaptive immunity

 On December 23, 2021, Professor Xu Jianqing from our hospital, the team of Professor Ye Lilin from the Army Military Medical University and Professor Yin Zhinan from the Institute of Translational Medicine of Jinan University published the title The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells on Nature Immunology .

 The researchers first established acute viral infection through lymphocytic choriomeningitis virus (LCMV), combined with bone marrow chimera model (BMC), in the memory CD4 T cell establishment phase (Day 21) and maintenance phase (Day 41), by knocking out Rictor gene to block mTORC2 signal, it is found that mTORC2 signal blocking will lead to a significant reduction of virus-specific memory CD4 T cells

 The death of iron was first defined by the team of Professor Brent Stockwell of Columbia University in 2012

 In terms of mechanism, researchers found that memory CD4 T cells maintain a relatively low but continuous (tonic) mTORC2 signal activity under the influence of the IL-7/IL-7R signaling pathway

 In summary, this study reveals for the first time the role and mechanism of the mTORC2 pathway in the long-term maintenance of memory CD4 T cells.

 The corresponding authors are Professor Ye Lilin from the Institute of Immunology of Army Military Medical University, Professor Yin Zhinan from the Institute of Translational Medicine of Jinan University, and Professor Xu Jianqing from the Institute of Biomedicine, Fudan University

Original link: https://doi.