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In August 2022, the international academic journal PLOS Pathogens published online the latest results of the team of researcher Zhou Xi from Wuhan Institute of Virology/State Key Laboratory of Virology, Chinese Academy of Sciences.
The title of the paper is "Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation"
.
This study found the pathogenic mechanism of echovirus-induced pyroptosis by promoting the activation of the NLRP3 inflammasome
.
The title of the paper is "Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation"
.
This study found the pathogenic mechanism of echovirus-induced pyroptosis by promoting the activation of the NLRP3 inflammasome
.
Echovirus 11 (ECHO11) belongs to the group B enteroviruses of the Enterovirus genus of the Picornaviridae family and is one of the most common enteroviruses
.
ECHO11 infection can lead to a wide range of diseases such as aseptic meningitis, upper respiratory tract infection, myocarditis and hepatitis
.
In recent years, frequent outbreaks of ECHO 11 have caused severe diseases, such as acute hepatitis, especially in neonates, with high morbidity and mortality
.
However, few studies on the pathogenic mechanism of ECHO11 have hindered the development of effective preventive and therapeutic strategies
.
.
ECHO11 infection can lead to a wide range of diseases such as aseptic meningitis, upper respiratory tract infection, myocarditis and hepatitis
.
In recent years, frequent outbreaks of ECHO 11 have caused severe diseases, such as acute hepatitis, especially in neonates, with high morbidity and mortality
.
However, few studies on the pathogenic mechanism of ECHO11 have hindered the development of effective preventive and therapeutic strategies
.
The team, in collaboration with Professor Xu Yi from Guangzhou Women and Children's Medical Center, isolated the ECHO11 strain from clinical samples of confirmed ECHO11-infected neonatal patients, which is 99.
95% identical to the gene sequence of the D207 strain (EF634316.
1).
homology
.
Further studies showed that ECHO11 can induce pyroptosis by promoting the activation of the NLRP3 inflammasome, and found that ECHO11 nonstructural protein 2B is a key protein in activating the NLRP3 inflammasome, and ECHO11 2B promotes the inflammasome by directly interacting with NLRP3.
The assembly and activation of ECHO11 2B identified the key amino acid sites for ECHO11 2B to function
.
The above conclusions were also confirmed in mice
.
This study revealed the molecular mechanism of ECHO11-induced pyroptosis for the first time, and provided new ideas and molecular targets for understanding the pathogenic mechanism of ECHO11 and the development of anti-ECHO11 drugs
.
95% identical to the gene sequence of the D207 strain (EF634316.
1).
homology
.
Further studies showed that ECHO11 can induce pyroptosis by promoting the activation of the NLRP3 inflammasome, and found that ECHO11 nonstructural protein 2B is a key protein in activating the NLRP3 inflammasome, and ECHO11 2B promotes the inflammasome by directly interacting with NLRP3.
The assembly and activation of ECHO11 2B identified the key amino acid sites for ECHO11 2B to function
.
The above conclusions were also confirmed in mice
.
This study revealed the molecular mechanism of ECHO11-induced pyroptosis for the first time, and provided new ideas and molecular targets for understanding the pathogenic mechanism of ECHO11 and the development of anti-ECHO11 drugs
.
Researcher Zhou Xi and Qiu Yang Youth Researcher of Wuhan Institute of Virology, Professor Xu Yi of Guangzhou Women and Children's Medical Center are the co-corresponding authors of the paper, Wang Chong, postdoctoral fellow of Wuhan Institute of Virology-Guangzhou Women and Children's Medical Center, and Yang Ruyi, a master student of Wuhan Institute of Virology Co-first author
.
The research was funded by the National Key R&D Program, Strategic Pilot B of the Chinese Academy of Sciences, and the National Natural Science Foundation of China
.
.
The research was funded by the National Key R&D Program, Strategic Pilot B of the Chinese Academy of Sciences, and the National Natural Science Foundation of China
.
Paper link: https://doi.
org/10.
1371/journal.
ppat.
1010787
org/10.
1371/journal.
ppat.
1010787
Figure 1.
ECHO11 nonstructural protein 2B induces NLRP3 inflammasome-dependent pyroptosis
ECHO11 nonstructural protein 2B induces NLRP3 inflammasome-dependent pyroptosis
