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Wu Hong's group from the School of Life Sciences Reveals a New Mechanism of Converting "Cold" Tumors to "Hot" Tumors to Promote Prostate Cancer Immunotherapy

 Last Update: 2022-02-19
 Source: Internet
 Author: User

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Prostate cancer is one of the leading causes of cancer death in men.

Abnormal activation of PI3K-AKT signaling pathway caused by PTEN deletion is the most common driver of prostate cancer

Intermittent BAY1082439 treatment converts "cold" tumors to "hot" tumors and promotes ICT therapy efficacy

Given that abnormal activation of the PI3K pathway is the most commonly upregulated signaling pathway in cancer, this study also provides a preclinical basis for the application of PI3K inhibitor-targeted therapy and combined immunotherapy for other tumors

Wu Hong is the corresponding author of this article

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