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For paralysis caused by severe spinal cord injury, millions of people around the world are affected by the disease, but there is currently no effective treatment
Surgeons at Keio University wanted to study whether induced pluripotent stem cells (iPS) could be used to treat this spinal cord injury
iPS cells work by stimulating mature, specialized cells back into a stem cell state and then inducing them to redifferentiate into different types of cells
The patient's cells are extracted for in vitro culture, and these cells are induced into various desired cells using iPS technology, and their replication ability can be used to repair damaged tissues or organs
Researchers at Keio University used iPS-derived neural stem cells to treat severe spinal cord injuries
In fact, the clinical trial was approved as early as 2019 after it was suspended due to the COVID-19 pandemic
It is reported that the research group transplanted more than 2 million iPS-derived neural stem cells into the spinal cord of a patient with spinal cord injury during an operation last month
The number of transplanted cells was determined based on previous animal experiments
Masa Nakamura, a professor at Keio University who led the study, said this is undoubtedly a big step forward for stem cell therapy
Much work remains to be done before the therapeutic range becomes too large, and the primary goal of this study is to determine the safety of the transplant approach
An independent committee monitoring patients for up to three months has determined whether the trial can safely continue and whether other trials can be treated
In addition, the research team hopes to see whether stem cell therapy can improve neurological function and quality of life in patients
Details of the patient are still being kept under wraps, and the team said the trial of stem cell therapy for spinal cord injuries will focus on patients with spinal cord injuries within 14-28 days
Previously, researchers at Kyoto University had used iPS cells to treat Parkinson's disease in 2018
https://medicalxpress.
