World's first gastric disease vaccine born in Chongqing

1982, Australian scholars Barry Marshall and Robin Warren isolated Helicobacter pylori (hp, an S-shaped or arc-bending Gram-negative bacteria that produces large amounts of urea enzymes that are resistant to acidic stomach strains and therefore not killed by stomach acid) from a biopsy sample of a patient with chronic gastritis, and have shown that the bacteria can cause gastritis, stomach ulcers and gastroenterologyThis important finding provides a valuable research direction for humans to explore treatments for diseases such as stomach ulcers, which, if ideally advanced, could mean a chance that patients such as stomach ulcers could be completely curedThe two scholars were awarded the 2005 Nobel Prize in Physiology/MedicineThe Nobel laureate discovered and determined that Helicobacter pylori is pathogenic to serious diseases such as gastritis, stomach ulcers and stomach cancer, but how to prevent and cure it? This is still a difficult problem that needs to be solved in front of the international medical communityThird Military Medical University and Chongqing Kang health products and technology co-developed the Helicobacter pylori gastric disease vaccine at the end of 2005 successfully completed Phase III clinical trial, which is the world's first to complete Phase III clinical trial of the gastric disease vaccine, the project has been applied for and obtained a national invention patent 6, the original innovation, with independent intellectual property rights of the country's new drugs, developed by our Chinese their own original vaccineThis marks a major breakthrough in the Nobel Prize proposition in Chongqing, ChinaThe news was also named China's top ten science and technology progress news in 2006Research style: innovation, diligence, down-to-earthChina is the hardest hit area of Hp bacteria infection, infection rate of up to 50%, the number of infections more than 600 million, China's annual death from stomach cancer more than 200,000 people, in the forefront of malignant tumor deaths, the annual cost of gastric disease prevention and treatment of more than 10 billion yuanIn 1995, the Third Military Medical University formed a task force to officially enter the field of gastric disease vaccineHowever, the development of a primitive and innovative new drug requires considerable capital investment and a lengthy development and testing process, with a very low success rateIn accordance with international practice, the development of an original and innovative class of new drugs (drugs not available at home and abroad) takes about six stages: project propositions, experimental research, small trials, pilot amplification, preclinical research, human clinical trialsResearch and development will cost about $500 million, and research will take 15 years or more, with a one-in-two-million chance of success from the drug pilot to the final screening, as well as a management system and soft environment that is matched with the development of new drugsIn the absence of the same vaccine reference, the researchers experienced numerous failures, overcome one technical difficulty after another, obtained tens of millions of experimental data, combined the spirit of innovation, innovation awareness and specific technical details, genetic engineering, protein engineering and other modern biotechnology and the original foundation closely linked, broke through many key technical problems in the development, obtained a number of original results: gastric disease vaccine design principles, seed engineering strains, process processes, test technology indicators, formula, quality standards, etcOne of the most representative is: the first creation of molecular adhesive mucosal vaccine theory, and the adoption of a unique genetically engineered vaccine molecular construction model, in the mucous membrane surface to produce immunity, solve the problem of Helicobacter pylori infection on the surface of the mucous membrane and difficult to prevent and control;Pathfinder to innovation, diligence, practical scientific research style, to ensure the stomach disease vaccine advanced, effective and safeIn 2002, three batches of gastric disease vaccine in one-time pilot products passed the technical test and identification of the China Drug Inspection Institute In 2003, it passed the academician and expert evaluation meeting organized by the National Center for the Review of New Drugs, becoming the only gastric disease vaccine approved for human trials in China In 2004, 653 people I, II human clinical trials were successfully completed in one another one-time, and the human immune positive rate was 91% Today, and successfully completed the pre-screening test of 10,000 people and 5000 people on-site testing, walking in the forefront of similar international research The world's first Helicobacter pylori vaccine is about to be born in Chongqing Institutional innovation: "production, learning, research" interactive more than 10 years ago, Chongqing not only does not have the original kind of new drug hardware and software, but also seriously underfunded, the research started, only the Third Military Medical University funded 25,000 yuan At that time, the area of scientific research only 80 square meters, simply can not meet the most basic conditions for the development of vaccines It is clearly not feasible to solve these enormous difficulties in the traditional way Only in the idea of innovation, innovation in the mechanism, another way is possible to obtain sufficient research and development funds, in order to improve and build a good research hardware, in order to absorb and stabilize scientific research personnel With the support of the school leaders, the project's chief expert, Professor Zhai Quanming, while grasping the technical problems, while mobilizing all the resources that can be mobilized, out of the campus, into the community, visiting enterprises, actively seeking to work with enterprises, more than a year has walked through the great river north and south, experienced countless times outside of professional and technical expertise bitter grinding and testing After several tribulations, the number is easy to its master In 1997, they took the project as a technology investment, and together with the investors set up a "production, learning, research" model of biological high-tech Co., Ltd., from then on, research and development funds have a stable source At the same time, the Chongqing Municipal Committee, the municipal government has given long-term care to the project, in particular, the Municipal Science and Technology Commission, the Drug Administration, the National Development and Reform Commission, the Commission, the Education Commission and the high-tech zone and other relevant departments to the project research and development funding and policy support, on this basis, the project has been listed as the national "15" major Science and technology special, "863" high-tech topics, the national "95" key issues, Chongqing city major scientific and technological research topics, military medical research projects, the National Natural Science Foundation of China, such as 20 scientific research projects, received vertical research funds of more than 10 million yuan In order to ensure the smooth progress of the project, in 1999, the task force in the leadership of the support, together with enterprises to "production, learning, research" model, self-financing more than 30 million yuan, design and construction of the international advanced level of GMP biopharmaceutical pilot workshop and incubation base Not only to meet the needs of the project research and development, but also the base in 2004 by the Municipal Science and Technology Commission approved as Chongqing Biopharmaceutical Engineering Technology Research Center, efficiently play a biopharmaceutical technology driving and radiation, personnel training and other composite functions, chongqing and the development of the national pharmaceutical industry is playing a positive role Talent innovation: to create a cradle of high-tech talent
1995, when the gastric disease vaccine was established, the group of 4 people only 1 doctoral degree recipient, the other 3 are recently graduated teaching assistants, the subject has not yet been awarded the right to master's degree Today, 10 years later, the task force has developed into a team of more than 50 bio-high-tech personnel, supported by the team, Professor Yu Quanming for the discipline leader in 2000, 2004 and 2005 respectively applied for the clinical test diagnostics, biotechnology and biopharmaceuticals three disciplines of the doctoral grant, and become a post-doctoral mobile site, in 2001 as the key discipline spool in Chongqing, is applying for the "115" national key disciplines So far, 85 post-doctoral, ph.D and master's students have been recruited and 320 senior guest sandals and trainees have been trained for Chongqing and the military In the innovation research, the advantages of cutting-edge technology and interdisciplinary disciplines are highlighted, and the virtuous circle of innovative research and the construction of subject talents has been realized (reproduced from China Youth Daily)