Without cranial, how can laser interstitial heat therapy (LITT) remove brain tumors step by step?

Advances in modern cutting-edge technology have brought new development to the diagnosis and treatment of intracranial tumors, and the survival expectations and survival rates of patients with brain tumors have been greatly improved, with magnetic resonance imaging MRI-led laser interstitial heat therapy (laser interstitial thermal therapy, LITT) playing a significant role
201 A paper published in July 2008 in Journal Oncology for the treatment of glioblastoma sedatives suggests that the use of MRI-guided laser interstitial heat therapy (LITT) is safe and effective for glioblastoma in some patients, with an average life expectancy of two months longer than current standard treatmentsIn May 2019, neurosurgery experts in the United States, among others, published a new method of staging LITT to treat a case of large, small-sudden glioblastoma (WHOII) in the leaves of the dominant hemispheric island, which represents a significant advance in laser heat therapyWhat is laser interstole heat therapy?laser interstitial heat therapy is a kind of perdertic minimally invasive surgery under stereotactic guidance, the laser acts on the target point through optical fiber, thus selectively ablation of lesionsThe biggest advantage of this technology is that it can achieve precision ablation therapy for deep lesions of the brain under real-time guidance and monitoring of magnetic resonancethis is a combination of imaging stereotactic navigation and microcatheter laser heat therapy of new technology, with laser precision positioning and temperature control advantages, applied to glioma, metastatic tumor, epilepsy and epidural metastatic treatmentLITT is a minimally invasive therapy that uses fine laser fiber (arrow) to direct real-time MR imaging to accurately destroy tumor tissuelitTt t-cut the lesions step by step?the mechanism of action of LITT technology, INC World Neurosurgery Advisory Group member, editor-in-chief of journal of neurosurgery, chief of surgery at the University of Toronto Children's Hospital, And chair professor james TRutka, chairman of the Brain Tumor Research Center, said laser interstitial heat therapy uses advanced magnetic resonance imaging MRI-led technology, where neurosurgeons can clearly identify the location of tumors with surrounding healthy brain tissue to develop precise surgical pathwaysThe surgical procedure first needs to cut a small incision about 2-4 mm wide on the skin of the affected part, then insert a laser fiber probe, and finally guide the probe to the location of the lesion sitoritpoint, using a pulsed laser to ablat or burn the tumor tissue(LITT surgical diagram)LITT to remove intracranial tumors of the 5 advantages
1, MRI technology guide the whole process, accurate positioning of lesions, to avoid damage to the surrounding healthy tissueA brain tumor with a diameter of 3cm can be treated in a single session, and the whole brain tumor needs to be abled through multiple trajectories for lesions with a diameter of 3cm2, minimally invasive, few complications: small surgical incision, scalp cut less than 4mm, skull drilling puncture can beNew treatment options are available for patients who are unable to tolerate craniotosis3, short surgery time, fast recovery: intracranial primary tumor average LITT time is 2.9 hours, most patients can go home the day after treatment, and can quickly return to normal activityPatients who undergo routine surgery are hospitalized for five to six days and then recover for several weeks4Safety: No radiation-induced tissue damage, can help stereotactic radiation surgery non-reactive or radioactive necrosis (tissue death caused by radiation therapy)5, applicable widely: post-radiation therapy bureau lesions recurrence of metastatic tumors, deep-seated malignant gliomas, flat-cooked recurrence of glioma and radioactive necrosis; Intracranial tumors with recurrent glioblastoma and other treatment difficulties can be treated in a repeated and multi-faceted wayneed to note that LITT can aggravate the tumor perimeter edema, so the tumor has caused a significant occupancy effect, should be carefulLITT's development historyIn 1983, Bown first described LITT technology, and Sugiyama first used LITT to treat brain lesions in 1990However, due to the lack of perfect early technology, it is impossible to effectively control the thermal damage of the tissue around the melting stove, which restricts the application of this technologyIn recent years, the rise of magnetic resonance-guided laser interstitial thermal therapy (MRg-LITT) has enabled real-time monitoring of the temperature of the ablation area during treatmentin 2007, the FDA approved the first MRg-LITT system for the treatment of encephalopathyin 2009, local laser interstitial heat therapy was approved by the FDA for the treatment of intracranial diseaseMRg-LITT was first applied to a child with epilepsy in 2010Currently, mRg-LITT is being used in multiple centers to treat brain metastatic tumors, radionoidos, gliomas, and epilepsy At present, this technique is one of the main treatment methods of the inner-type epilepsy of the temporal lobe, and its clinical application will be further expanded A paper published in Cancer Imaging in October 2019 points out that LITT is considered a less invasive technique than traditional craniofacial surgery, showing encouraging results in the treatment of gliomas, brain metastatic tumors, radiation necrosis and epilepsy, providing safer alternative treatment options for patients who are unable to access the lesions through surgery, not for surgical candidates or other standard treatment options In general, laser interstitial heat therapy (LITT) is a new method of minimally invasive treatment of intracranial lesions with wide application At present, some of the world's leading neurosurgery professional research institutions, LITT technology is getting more and more mature applications, such as the world-renowned University of California, San Francisco Medical Center (UCSF), the InI International Neurology Research Center in Germany and Lariboisiere Hospital in Paris, France, one of the world-class children's hospitals, the University of Toronto Children's Hospital sickKids However, the current clinical studies are mostly retrospective studies of small samples, and the results do not strictly distinguish the nature and location of lesions, with limited guiding significance For further guidance on the application of LITT, multi-center, large samples, and prospective clinical research results are also needed as a basis Source: INC International of Neuroscience