Why is pancreatic cancer so deadly? The latest research has uncovered new tools to improve pancreatic cancer treatment

The statistics on pancreatic cancer are thought-provoking

One way to extend survival is to optimize treatment strategies and switch strategies in a timely manner when treatment is ineffective

From junk to gold

A study published today (September 9) by the Systems Oncology Laboratory at the Champalimaud Research Center provides a potential game changer for how to assess treatment response in patients with

Bruno Costa-Silva, the study's lead researcher and senior author, first explored the potential

Considering that plants and bacteria also release these small bubbles, electric vehicles may be one

In previous studies, Costa-Silva found that EVs in the blood can be used to detect, predict, and localize pancreatic cancer metastases

From idea to discovery

When Nuno Couto, an oncologist at the Champarud Foundation and lead author of the study, set out to investigate the potential of electric vehicles in monitoring response to treatment, the team found a surprising result

Kuto admits: "The next step is the most challenging

Using a special method developed in the Costa-Silva lab to rapidly measure EV populations in tiny blood samples, the research team found that igg-positive EVs increased during disease progression and decreased

Costa-Silva said: "We are very excited to see the close link

From oncology to cell biology

Costa-Silva asserts, "This discovery has led me to change the direction of

The researchers found that in PDAC patients, IgG binds

Costa-Silva pointed out: "If a highly aggressive cancer like PDAC uses ev to relieve the immune system, we can develop new therapies for tumor-derived EVs that reduce the treatment resistance of these cancers

As Costa-Silva puts it, "It's about cell physiology

Costa-Silva added: "There's a lot we don't know about how cells communicate with each other

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IgG+ extracellular vesicles to detect therapeutic response in advanced pancreatic cancer