Malaria invades red blood cells, which is a key stage of its life cycle
Why do some people get serious illnesses after being infected with the malaria parasite, while others carry the infection asymptomatically? Recently, researchers may have found the answer
An international research team used large-scale cell counting technology (a method for in-depth analysis of individual cell characteristics) and machine learning to find "immune signals" related to symptomatic or asymptomatic infections in people infected with malaria parasites
The research was published in JCI Insight and was led by Lisa Ioannidis and Diana Hansen of WEHI, an Australian medical research institute
JCI Insight Malaria is a parasitic disease that affects hundreds of millions of people every year
The immune response to malaria is a "double-edged sword," Hansen said.
Using the large-scale cell testing equipment of the University of Melbourne, the research team conducted an in-depth and multi-dimensional evaluation of immune cells in blood samples provided by residents of malaria-endemic areas in Indonesia
The researchers said that the antibodies produced by B cells are an important component, especially in people with high parasite loads and symptomatic diseases, and certain types of CD4 T cells are essential for controlling infections and preventing symptoms
Related paper information: http://dx.
http://dx.
doi.
org/10.
1172/jci.
insight.
148086
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