Whether the genetic risk is high or low, doing these points can reduce the risk of breast cancer.

▎ the editor of YaoMing Kant content team is suffering from cancer, and the whole family is worried! That's true.once someone has cancer in a family, the whole family, even the whole family, will be affected.not only do you worry about your family suffering from cancer, but you also worry about yourself.because many cancers are hereditary, such as breast cancer, the most common cancer among women in the world. The incidence rate and mortality rate of breast cancer inare the highest in female cancer, which is closely related to heredity and lifestyle.however, genetic factors cannot be changed, and changes in lifestyle will have an impact on the occurrence of breast cancer.recently, a study published in the Journal of the American Medical Association, JAMA network open, showed that a healthy lifestyle is associated with a lower risk of breast cancer, even among women with high genetic risk.source: to assess whether a healthy lifestyle can reduce the risk of breast cancer in people with different genetic risks, researchers from the University of Manchester in the UK Pixabay analyzed data from UK Biobank, the largest human genetic cohort sample bank in the world, involving more than 90 thousand female subjects over the age of 40.the researchers analyzed the lifestyles of the subjects and divided them into healthy (≥ 4), moderately healthy (2-3) and unhealthy (≤ 1) lifestyle groups according to the number of five healthy lifestyles they followed.the five healthy lifestyles were regular exercise, maintaining a healthy weight, not drinking or limiting drinking (< 3 times / week), not taking oral contraceptives and not using hormone replacement therapy for at least 5 years.in addition, the genetic risk of breast cancer was assessed by polygenic risk score, and the subjects were divided into high, medium and low genetic risk groups.during an average follow-up of 10 years, a total of 2728 subjects developed breast cancer.Image Source: pixabay researchers found that about 23.3% of the subjects followed a healthy lifestyle; 68.0% followed a moderately healthy lifestyle; and 8.6% had an unhealthy lifestyle.compared with non breast cancer subjects, subjects with breast cancer generally had higher body mass index (BMI), less exercise, more use of hormone replacement therapy for more than five years, more oral contraceptives and more alcohol intake than non breast cancer subjects.from the perspective of genetic risk, compared with subjects without family history of breast cancer, the risk of breast cancer increased by 49% in one of the first-class family members (mother or sister) and 110% in subjects with two first-class family members suffering from breast cancer.in terms of lifestyle, the less healthy lifestyle followed, the higher the risk of breast cancer.compared with the healthy lifestyle group, the risk of breast cancer increased by 25% in the moderate health group and 44% in the unhealthy group. specifically, unhealthy weight (BMI ≥ 25), irregular exercise, drinking at least three times a week, and using hormone replacement therapy for more than five years were associated with an increased risk of breast cancer by 14%, 12%, 11% and 23%, respectively. however, there was no significant correlation between the history of oral contraceptives and the increased risk of breast cancer. in addition, in subjects with the same genetic risk, not following a healthy lifestyle also increased the risk of breast cancer. compared with the subjects in the healthy life group, the risk of breast cancer was increased by 40% and 63% in the moderate and unhealthy groups in the low genetic risk group, 37% and 94% in the moderate and unhealthy groups, respectively, in the high genetic risk group, while in the high genetic risk group, the risk of breast cancer was increased by 40% and 63% in the moderate and unhealthy groups, respectively Breast cancer risk increased by 13% and 39%, respectively. Image Source: pixabay, as this study is an observational study, only shows a correlation between a healthy lifestyle and a lower risk of breast cancer, and does not show a causal relationship. moreover, the subjects in the study were mainly postmenopausal women, and they did not differentiate the types of breast cancer, which may have an impact on the results of the study. however, the researchers concluded that a healthy lifestyle reduced the risk of breast cancer in women, and even women with a higher genetic risk could reduce their risk of breast cancer by following more healthy lifestyles. commenting on the study, Dr. Charles Shapiro of the Icahn School of medicine in Mount Sinai, New York, commented: "the results are surprising. These healthy lifestyles not only reduce women's risk of breast cancer, but also promote their overall health. "previous studies have shown that maintaining a healthy weight, exercising more, not drinking or limiting alcohol consumption can also reduce the risk of cardiovascular disease and prolong disease-free life. "healthy life" is not only a slogan, but also a life attitude and responsibility for one's own health and life safety. I hope everyone can adopt a healthy lifestyle and work hard for their own health and life safety. reference [1] kawthar al ajmi, et al., (2020). Association of nongenetic factors with breast cancer risk in genetically predisposed groups of women in the UK Biobank Cohort. JAMA network open, DOI: 10.1001/jamanetworkopen.2020.3760. [2] lifestyle choices may reduce cancer risk regardness of genetics. Retrieved Jul 9, 2020, from #vp_ Note: the purpose of this article is to introduce the progress of medical and health research, not to recommend treatment options. if you need guidance on treatment plan, please go to a regular hospital.