What is trypsin inhibitor?

Trypsin is an enzyme that breaks down proteins in the digestive system Trypsin inhibitor is a substance that can prevent trypsin from breaking down proteins or reducing the enzyme's potency Therefore, trypsin inhibitors can reduce the amount of protein absorbed by the gastrointestinal system from food In addition to being found in certain foods, the pancreas of the human body and cattle can also secrete this inhibitory enzyme Trypsin is produced in the pancreas together with chymotrypsin Both enzymes are serine proteases, meaning they break down proteins into small peptide pieces Food protein is first digested by pepsin, then trypsin After binding the protein to the active site of the enzyme, trypsin cleaves the protein at specific sites of lysine and arginine Trypsin inhibitors can bind to this active site and block further proteolysis Trypsin inhibitors are produced by the secretion of the pancreas, because trypsin is a threat to cells The pancreas stores a precursor form of trypsin called trypsinogen This trypsinogen usually needs to be released into the small intestine to be converted into trypsin Trypsin inhibitor is a safe mechanism for trypsinogen transformation and trypsin release Trypsin inhibitors and trypsin are proteins, which means they are all made of amino acids Trypsin inhibitors block many types of enzymes For example, trypsin from bovine pancreas is composed of 229 amino acids The trypsin inhibitor of cattle is made of 58 amino acids, and has the function of preventing bovine trypsin, human trypsin and chymotrypsin One milligram of bovine trypsin inhibitor is needed to block 1.5 milligrams of trypsin Some foods also contain trypsin inhibitors Such as soybeans, lima beans and egg white Plant trypsin inhibitors can also be used as insect repellents, because they can affect the normal activities of insect viscera Human milk also contains trypsin inhibitors Trypsin inhibitors of human milk protect the intestinal cell wall of infants from damage Trypsin is widely used in experiments, such as cell culture, tissue separation into constituent cells, gene analysis, sample preparation and protein research Trypsin inhibitors can be used to stop further damage to trypsin during the experiment Commercial trypsin inhibitors can be obtained from bovine pancreas, soybean, lima bean or egg white.