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Scientists have successfully identified human genetic variants associated with obsessive compulsive disorder (OCD) and found genes and neural pathopathies affected by these mutations, according to a genetic paper published online in the British journal Nature Communications.
separating and characterating these genes will help us understand the biology behind the disease and thus establish effective treatments.
people often say they are suffering from obsessive compulsive disorder.
but the cause of obsessive-compulsive disorder is complex, undetermined, but has a strong hereditary.
this exhaustive neuropsychiatic disease is strongly associated with personality and psychological factors, as well as the imbalance in the secretion of neurotransmitters in the brain, mainly in the form of invasive thinking and time-wasting repetitive behavior.
statistics in recent years show that the incidence of obsessive-compulsive disorder is on the rise, with more than 80 million people worldwide suffering from obsessive-compulsive disorder, most of whom are unable to benefit from existing treatments.
previous studies in humans, mice and dogs have also identified mutations that may be associated with obsessive-compulsive disorder, but the exact genes and variants have not been identified in humans.
, a team of scientists at the Harvard-MIT Broad Institute successfully identified four genes closely associated with obsessive-compulsive disorder in human cases by analyzing sequencing data from 608 candidate genes.
these genes play a role in neural pathways associated with obsessive-compulsive disorder, including serotonin and glutamate signaling and synaptic associations -- they are likely to be potential drug targets.
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