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*Only for medical professionals to read for reference.
What is the significance of tonic test C-reactive protein and erythrocyte sedimentation rate? Clinical data shows that ankylosing spondylitis is often accompanied by joint disease, invades cardiovascular, lung, kidney, eyes, ears and other tissues and organs, and is complicated by a variety of diseases, and even some seem to be "unrelated to rigidity.
" , Complicated and confusing symptoms, easy to misdiagnose and mistreatment
.
(Source: Photograph.
com) In fact, it is not difficult to diagnose rigidity, but early diagnosis is difficult
.
How to diagnose rigidity? Clinically, inflammatory spondyloarthropathy should be considered based on the patient's medical history and the following manifestations
.
①Insidious low back and back discomfort; ②Age<40 years old; ③Related symptoms lasting more than 3 months; ④Stiffness in the morning; ⑤Symptoms improved after exercise; ⑥Having the above medical history, X-rays showing signs of sacroiliitis , Which is confirmed as spondyloarthropathy
.
Combining the above performance, and then further excretion of psoriasis and inflammatory bowel disease, the diagnosis of ankylosing spondylitis can be made, instead of waiting until the spine is clearly rigid
.
What is the significance of tonic testing of C-reactive protein and erythrocyte sedimentation rate? C-reactive protein is an acute-phase protein.
It is like a guardian.
When the body is in a variety of acute and slow infections, it will come forward and protect the body from external interference by activating the human immune system
.
Therefore, the detection of C-reactive protein is significantly increased, which is an obvious indicator of inflammation
.
(Source: Photograph.
com) ESR can be significantly increased in the early stage of acute activity of autoimmune diseases.
It is like a mirror that can reflect whether the body's condition is abnormal
.
Studies have shown that in patients with rigidity, where imaging findings suggest abnormalities, there will be significant changes in serum C-reactive protein and erythrocyte sedimentation rate.
.
Among the patients with ankylosis, the X-ray hip joint involved, the serum C-reactive protein and erythrocyte sedimentation rate were significantly higher than those with hip pain symptoms but normal X-ray
.
The latter two levels were significantly higher than those without hip joint involvement
.
According to the involvement and clinical manifestations of the joints, lumbar spine and sacroiliac joints reflected by imaging studies, ankylosis can be divided into a stationary phase, a lightly active phase, and an active phase
.
The study found that the serum C-reactive protein level was significantly higher in the active phase than in the other two phases, and it was positively correlated with the degree of joint erosion and sclerosis shown by CT and the clinical manifestations of low back pain and stiffness
.
With the reduction of the treatment, the level of C-reactive protein will gradually return to normal
.
This indicates that elevated levels of C-reactive protein indicate that tonicity is in the active phase
.
In short, through the determination of C-reactive protein and erythrocyte sedimentation rate indicators, it is mainly used to judge the inflammatory activity of the disease, and the degree of change can reflect the progress of the disease
.
Is HLA-B27 positive diagnosis rigid? Rigidity patients, regardless of race and region, have been shown to be associated with human leukocyte antigens, that is, HLA-B27 is strongly associated with rigidity, and its intensity ranks first among diseases associated with human leukocyte antigens.
In patients with rigidity, HLA-B27 is positive The rate can be as high as 90%~96%
.
The literature reports that HLA-B27 is used to diagnose rigidity, and its diagnostic coincidence rate can be as high as 95%
.
It was also found that some patients with low back and leg pain or repeated bilateral sacroiliac joint soreness showed no abnormalities in X-ray examination, but HLA-B27 showed weak positive results, which provided a basis for early diagnosis
.
(Source: Photograph Network) It is worth noting that the positive rate of HLA-B27 in the general population in China is 5%~7%, and the positive rate of serum rheumatoid factor in rheumatoid patients is only 70%~80%, and the remaining 20% ~30% are negative
.
Therefore, HLA-B27 and rheumatoid factor test results alone are not enough to confirm or deny the diagnosis of rigidity
.
Therefore, HLA-B27 is generally not used to diagnose rigidity.
It must be combined with other clinical data, especially imaging examinations and other comprehensive judgment analysis to ensure the correctness of the early diagnosis of rigidity
.
Source of this article: Rheumatism Runyue Shuo Author of this article: Runyue Medical Responsibility Editor: Cassette copyright statement
What is the significance of tonic test C-reactive protein and erythrocyte sedimentation rate? Clinical data shows that ankylosing spondylitis is often accompanied by joint disease, invades cardiovascular, lung, kidney, eyes, ears and other tissues and organs, and is complicated by a variety of diseases, and even some seem to be "unrelated to rigidity.
" , Complicated and confusing symptoms, easy to misdiagnose and mistreatment
.
(Source: Photograph.
com) In fact, it is not difficult to diagnose rigidity, but early diagnosis is difficult
.
How to diagnose rigidity? Clinically, inflammatory spondyloarthropathy should be considered based on the patient's medical history and the following manifestations
.
①Insidious low back and back discomfort; ②Age<40 years old; ③Related symptoms lasting more than 3 months; ④Stiffness in the morning; ⑤Symptoms improved after exercise; ⑥Having the above medical history, X-rays showing signs of sacroiliitis , Which is confirmed as spondyloarthropathy
.
Combining the above performance, and then further excretion of psoriasis and inflammatory bowel disease, the diagnosis of ankylosing spondylitis can be made, instead of waiting until the spine is clearly rigid
.
What is the significance of tonic testing of C-reactive protein and erythrocyte sedimentation rate? C-reactive protein is an acute-phase protein.
It is like a guardian.
When the body is in a variety of acute and slow infections, it will come forward and protect the body from external interference by activating the human immune system
.
Therefore, the detection of C-reactive protein is significantly increased, which is an obvious indicator of inflammation
.
(Source: Photograph.
com) ESR can be significantly increased in the early stage of acute activity of autoimmune diseases.
It is like a mirror that can reflect whether the body's condition is abnormal
.
Studies have shown that in patients with rigidity, where imaging findings suggest abnormalities, there will be significant changes in serum C-reactive protein and erythrocyte sedimentation rate.
.
Among the patients with ankylosis, the X-ray hip joint involved, the serum C-reactive protein and erythrocyte sedimentation rate were significantly higher than those with hip pain symptoms but normal X-ray
.
The latter two levels were significantly higher than those without hip joint involvement
.
According to the involvement and clinical manifestations of the joints, lumbar spine and sacroiliac joints reflected by imaging studies, ankylosis can be divided into a stationary phase, a lightly active phase, and an active phase
.
The study found that the serum C-reactive protein level was significantly higher in the active phase than in the other two phases, and it was positively correlated with the degree of joint erosion and sclerosis shown by CT and the clinical manifestations of low back pain and stiffness
.
With the reduction of the treatment, the level of C-reactive protein will gradually return to normal
.
This indicates that elevated levels of C-reactive protein indicate that tonicity is in the active phase
.
In short, through the determination of C-reactive protein and erythrocyte sedimentation rate indicators, it is mainly used to judge the inflammatory activity of the disease, and the degree of change can reflect the progress of the disease
.
Is HLA-B27 positive diagnosis rigid? Rigidity patients, regardless of race and region, have been shown to be associated with human leukocyte antigens, that is, HLA-B27 is strongly associated with rigidity, and its intensity ranks first among diseases associated with human leukocyte antigens.
In patients with rigidity, HLA-B27 is positive The rate can be as high as 90%~96%
.
The literature reports that HLA-B27 is used to diagnose rigidity, and its diagnostic coincidence rate can be as high as 95%
.
It was also found that some patients with low back and leg pain or repeated bilateral sacroiliac joint soreness showed no abnormalities in X-ray examination, but HLA-B27 showed weak positive results, which provided a basis for early diagnosis
.
(Source: Photograph Network) It is worth noting that the positive rate of HLA-B27 in the general population in China is 5%~7%, and the positive rate of serum rheumatoid factor in rheumatoid patients is only 70%~80%, and the remaining 20% ~30% are negative
.
Therefore, HLA-B27 and rheumatoid factor test results alone are not enough to confirm or deny the diagnosis of rigidity
.
Therefore, HLA-B27 is generally not used to diagnose rigidity.
It must be combined with other clinical data, especially imaging examinations and other comprehensive judgment analysis to ensure the correctness of the early diagnosis of rigidity
.
Source of this article: Rheumatism Runyue Shuo Author of this article: Runyue Medical Responsibility Editor: Cassette copyright statement
