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WCLC 2022｜NADIM II study: ctDNA levels before treatment are significantly correlated with OS and PFS

 Last Update: 2022-08-20
 Source: Internet
 Author: User

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The 2022 International Association for the Study of Lung Cancer (IASLC) World Conference on Lung Cancer (WCLC) kicked off from August 6 to 9, 2022 in an offline + online format

At this year's WCLC conference, a number of studies focused on perioperative immunization and targeted therapy

background:

Nivolumab + chemotherapy was approved by the FDA in March 2022 for neoadjuvant treatment of early-stage non-small cell lung cancer (NSCLC) based on the Phase III CheckMate816 study results

method:

NADIM II is an open-label, randomized, two-arm, phase II, multicenter clinical trial

result:

The median follow-up time was 26.

in conclusion:

Baseline ctDNA levels clearly identify patients at higher risk of disease progression and death and can be used to guide subsequent treatment decisions
.

ctDNA levels can increase prognostic information about OS and PFS
.

In addition, pre-treatment ctDNA levels significantly correlated with tumor size
.
Reference: MA06.
03 - Pre-treatment ctDNA Levels Significantly Predicts of OS and PFS in NADIM II Trial.
2022 WCLC.

Editor: Xiaoyuan
Typesetting: Xiaoyuan
Execution: Uni

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