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A long-term high-salt diet in humans can easily cause a series of diseases such as high blood pressure, heart disease, kidney disease, and cerebral hemorrhage.
On April 4, 2022, the research team of Wang Dehua and Zhang Xueying from the Institute of Zoology, Chinese Academy of Sciences published a research paper entitled "The microbiota-gut-kidney axis mediates host osmoregulation in a small desert mammal" in the international journal npj Biofilms and Microbiomes , finding that The regulation effect of gut microbiota and host kidney on high-salt-induced water and salt metabolism was investigated, and the regulation mechanism of "microbiota-gut-kidney" axis on high-salt tolerance in desert rodents was elucidated
In this work, the researchers induced a high-salt water-deficient model by feeding gerbils with normal rat chow and 4% or 8% of high-salt drinking water for 4 weeks, respectively, to study the kidney damage caused by high-salt water-deficient and changes in intestinal physiology and intestinal microecology; in addition, animals with 8% high salt intake were transplanted with intestinal flora derived from normal animals, and continued to drink 8% high saline to study the intestinal flora of normal animals Whether it can alleviate the damage caused by high salt intake
Zahra Nouri, a doctoral student at the Institute of Zoology, Chinese Academy of Sciences, and Zhang Xueying, associate researcher, are the co-first authors of the paper, and Wang Dehua, a researcher at the Institute of Zoology, Chinese Academy of Sciences, a researcher at the Center for Excellence in Biological Interaction, Chinese Academy of Sciences, a professor at the School of Life Sciences, Shandong University, and a deputy in the Institute of Zoology, Chinese Academy of Sciences.
Article information and links: Nouri Z, Zhang XY, Khakisahneh S, Degen AA, Wang DH.
https://doi.
Figure 1 Microbiota transplantation remodels gut microecology to alleviate high-salt-induced osmotic pressure
Figure 2 Schematic diagram of the "microbiota-gut-kidney" axis mediating high-salt-induced osmotic regulation
