-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
On December 14, 2021, the international academic journal mBio published online a research paper entitled "Inductive production of the iron-chelating 2-pyridones benefits the producing fungus to compete for diverse niches" by Wang Chengshu's research group
.
This work reported that when the entomopathogenic fungus Beauveria bassiana competes with other fungi, it induces the production of 2-pyridone compounds with iron ion chelating activity, which helps Beauveria bassiana to antagonize other fungi and deal with iron deficiency.
Beauveria bassiana is widely used in the biological control of agricultural and forestry pests.
The genome of this bacteria contains secondary metabolic gene clusters that synthesize different active ingredients.
However, under normal culture conditions, they are mostly silent.
Different gene clusters are responsible for the structure and structure of metabolites.
The activity, synthesis mechanism, and biological function are unclear
.
The previous research of the research group showed that when Beauveria bassiana and Metarhizium Roberts mixed infect insects, the former acted as a "weak person", that is, it could not compete with Metarhizium anisopliae to infect the same individual insect under the same spore concentration; but in vitro Under culture conditions, Beauveria bassiana can inhibit and repel the growth of Metarhizium anisopliae, thus exhibiting adaptive environmental competition ( J.
The research in this paper found that the mixed fermentation of Beauveria bassiana and Metarhizium anisopliae can induce the production of a new class of compounds
.
Structural identification showed that this class of compounds are 2-pyridone alkaloids, which are synthesized by the conservative polyketide synthase and non-ribosomal polypeptide synthetase (PKS-NRPS) TenS gene cluster, which only exists in Beauveria bassiana , And it is silent in pure culture
This work enriched the biosynthesis and regulation mechanism of 2-pyridone alkaloids, and proved that 15-HT, which has iron chelating function, has important ecological functions for Beauveria bassiana
.
Dr.
Chen Bo and Sun Yanlei, graduate students of the Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences, are the co-first authors, and researcher Wang Chengshu is the corresponding author
.
This research was funded by the National Foundation of China Innovation Group and the Frontier Science Key Research Program of the Chinese Academy of Sciences
Link to the paper: https://journals.
Beauveria bassiana synthesizes 2-pyridone and its series of precursors and derivatives (red markers are newly identified compounds)
