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Viterilol RIP1 inhibitor SIR1-365 starts clinical trials in China

 Last Update: 2022-01-05
 Source: Internet
 Author: User

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ArticleMedicine Guanlan

The Chinese drug clinical trial registration and information disclosure platform shows that Sironax (Sironax)'s first class 1 new drug SIR1-365 approved for clinical use has initiated a single-dose and multiple-dose safety and pharmacokinetics Study, Phase 1 clinical study

Screenshot source: Chinadrugtrials

Public information shows that SIR1-365 is a receptor-interacting protein 1 (RIP1) inhibitor

According to the official website of Viterilon, in animal experiments, inhibiting RIP1 kinase through small molecule drugs or gene editing can effectively prevent or reduce the development of a series of diseases, including multiple sclerosis (EAE model), Alzheimer's disease, amyotrophic lateral sclerosis, systemic inflammatory response syndrome

Previously, Viterilon has registered in the United States to carry out a phase 1 clinical trial to study the safety and effectiveness of SIR1-365 in patients with severe COVID-19

The study plans to enroll 20 people in China

▲Vite Ruilong product pipeline (picture source: Viteri Long official website)

Viterilon was established in 2018 to develop inhibitors for major discoveries in a variety of cell death fields, including apoptosis and necrosis

According to the official website of Viterilon, the current RIP1 inhibitor project (SIR1) has become the fastest-growing product in the research pipeline of Viterilon

Reference materials:

[1] Drug clinical trial registration and information disclosure platform.

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