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Some viral diseases may cause neurodegeneration
Misfolded proteins aggregate in so-called prion diseases (such as Creutzfeldt-Jakob disease) and have the ability to pass from one cell to another, where they transfer their abnormal shapes to the same type of protein
Cell culture experiment
Based on this hypothesis, Vorberg's team, with the support of DZNE colleagues in Munich, Tübingen and Belgian scientists, conducted a series of extensive studies on different cell cultures
Ligand promotes aggregate diffusion
"We can prove that viral proteins are incorporated into both cell membranes and extracellular vesicles
Potential effects on neurodegeneration
"The brains of patients with neurodegenerative diseases sometimes contain certain viruses
DOI
10.
Article title
Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions
