Viral Immunol: is it really possible to develop a broad-spectrum and effective dengue vaccine?

May 15, 2019 / BIOON / - dengue fever is on the rise About 20000 patients die of this mosquito borne disease every year However, despite continuous efforts, there is still no widely effective dengue vaccine A thought-provoking article recently published in viral immunology focuses on the complex challenges faced by dengue vaccine, its development status, and whether it is possible to develop an effective vaccine Photo source: http://cn.bing.com this article entitled "effective dengue vaccines: a pipe dream?" was co authored by L á Zaro Gil and Laura Lazo of the center for genetic engineering and Biotechnology (cigb), Havana, Cuba The authors note that dengue cases have increased tenfold over the past decade, and they reviewed efforts to develop a dengue vaccine, including extensive animal research and clinical trials, leading to the approval of dengvaxia from Sanofi Pasteur However, the use of the vaccine is limited because in some cases it actually increases the risk of severe dengue fever, for example, not being able to vaccinate children under the age of nine In view of the recurrence of viral diseases such as measles, rubella and poliomyelitis, the authors suggest that live attenuated dengue vaccine may need to be dosed more Based on past experimental evidence, the authors conclude that an effective dengue vaccine is possible, but still a great challenge, and they suggest that several existing concepts be reconsidered in the ongoing efforts to develop candidate dengue vaccines Dr David L woodland, editor in chief of viral immunology magazine, said: "recently, the food and Drug Administration approved the first dengvaxia vaccine, which is an important step in controlling dengue fever But the disease is complex, and in some cases, denghuaxia can cause serious side effects Gil and Lazo's excellent review highlights the complex issues of dengue vaccine " (BIOON Com) reference: l á Zaro Gil et al, effective dengue vaccines: apipe dream? Viral Immunology (2019) Doi: 10.1089/vim.2019.0044