-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
In a new study, researchers from NYU Langone Health have found that an amino acid called valine, a molecular building block of many animal proteins, plays an important role in T-cell acute lymphoblastic leukemia.
The authors found that blocking these valine-related genes not only resulted in reduced valine in leukemia T cells, but also stopped these tumor cells from growing in the lab
In addition, experiments showed that the most common NOTCH1 gene change (mutation) in patients with leukemia promotes cancer growth in part by increasing valine levels
The new study carried out experiments using human leukemia cells grown in the laboratory and transplanted into mice, which then developed the leukemia, which originates from white blood cells in the bone marrow
Further experiments showed that feeding these leukemia mice a low-valine diet for three weeks interrupted tumor growth
The authors plan to test over the next year whether a diet low in valine, such as meat, fish and beans, is an effective treatment for cancer patients
Co-corresponding author Dr.
The drug combination is important, he said, because such dietary restrictions are unlikely to last long-term
The American Cancer Society estimates that more than 1,500 Americans, mostly children, die each year from T-cell acute lymphoblastic leukemia
Note: The original text has been deleted
References:
Palaniraja Thandapani et al.
