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| Using single-cell sequencing to analyze human embryonic spinal cord development |
Dai Jianwu's team from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences and Nanjing Gulou Hospital professor Hu Yali's team used single-cell transcriptome technology for the first time to analyze the human embryonic spinal cord during early and second pregnancy
.
Related research was recently published in EMBO Reports, the journal of the European Society of Molecular Biology
Hu Yali’s team used single-cell transcriptome technology to analyze the human embryonic spinal cord during early and second pregnancy for the first time
In the new research, the collaborative team used the combination of cell nucleus and cell technology to sequence embryos at 7-23 weeks of gestation based on the characteristics of spinal cord tissue structure, axon length and myelin protein content of spinal cord cells, etc.
The developmental process of the spinal cord from neuron generation to differentiation of astrocytes and oligodendrocytes
.
A systematic analysis of neurons and glial mass spectrometry was carried out, and the time nodes of neurogenesis and glial occurrence in the development of human spinal cord were determined, and the composition and proportion of neuronal cell types at different time points were analyzed
Through the comparative analysis of the spinal cord single-cell data at the corresponding developmental stages of humans and mice, the similarities and differences in spinal cord development between species are analyzed
.
Finally, a subgroup of EGFR+ precursor cells with temporal and spatial specificity in the development of human spinal cord was discovered and analyzed.
The research was supported by the Special Fund for Strategic Leading Science and Technology of the Chinese Academy of Sciences and the National Natural Science Foundation of China
.
(Source: Feng Lifei, China Science News)
Related paper information: https://doi.
https://doi.
org/10.
15252/embr.
202152728
