Use of pharmaceutical grade sodium stearyl fumarate CAS4070-80-8

Pharmaceutical grade sodium stear fumarate CAS4070-80-8 uses sodium stearyl fumarate for the reaction of stearyl alcohol and maleic anhydride, and isomerizes the reaction product into salt, that is, sodium stearyl fumarate
.
Sodium stearate fumarate is a hydrophilic lubricant used as a lubricant for Chemicalbook in pharmaceutical excipients, which can overcome many problems related to magnesium stearate, such as the main drug is affected, over-lubrication; The formation of a protective film in effervescent tablets improves disintegration, promotes dissolution and thus increases bioavailability
.
Sodium stearate fumarate (C22H39NaO4) is a widely used and important pharmaceutical and food excipient.

In the metabolic process of sodium stear fumarate in animals, most of it can be absorbed, hydrolyzed to produce stearyl alcohol and stearic acid, and a small part can be directly and quickly metabolized out, with no irritation
.
In the field of pharmaceuticals, sodium stearate fumarate is added to pharmaceutical preparations, which can be used as lubricants for agents and capsules, and can also form a protective film in effervescent tablets, which can solve the problems existing in stearate lubricants, and coltan plays a role
in improving drug disintegration and promoting drug dissolution.
This product is (E)-butenedioate sodium
.
According to the anhydrous calculation, the content of C22H39NaO4 should be 99.
0%~101.
5%.

【Properties】This product is white or off-white powder, can be with flat spherical particle agglomerates
.
This product is slightly soluble in methanol and almost insoluble
in water, ethanol or acetone.
Saponification value take about 0.
45g of this product, weigh it accurately, put it in a 250ml reflux flask, add 50ml of 0.
55% potassium hydroxide anhydrous ethanol solution (newly prepared), heat reflux for 2 hours, rinse the inner wall of the condenser tube with 10ml of 70% ethanol solution, rinse 3 times with water, 10ml each time, cool to room temperature, wash 2 times with 70% ethanol solution, 10ml each time, add 1.
0ml of phenolphthalein indicator solution, use hydrochloric acid titration solution (0.
1mol / L) Titrate until the pink color of the solution just fades, and do a blank test
at the same time.
Calculated by the following formula, the saponification value should be 142.
2~146.
0
.
【Identification】(1) The infrared light absorption spectrum of this product should be consistent with the spectrum of the reference substance (General rule 0402).

(2) This product shows the reaction of sodium salt identification (1) (General 0301).

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