U.S. scientists find non-rejected bone marrow transplant method

researchers at Stanford University's California School of Medicine have found a new method of bone marrow transplantation that could lead patients to avoid serious side effects after bone marrow transplantsIn animal experiments, the researchers used a special antibody that removed bone marrow stem cells from the mice's bones, and newly implanted stem cells could be replaced, avoiding rejection and protecting patients from radiation and chemotherapyThe results were published in the latest issue of the American journal ScienceThe researchers gave mice an antibody that carried c-kitc-kit is a surface receptor of hematopoietic stem cells that promotes stem cell differentiation and improves survivalInjecting back2 in animal bone marrow inhibits c-kit function, and after 8 days, antibodies carrying c-kit removed more than 98% of the hematopoietic stem cells from miceSix months later, the transplanted hematopoietic stem cells grew at 90% of the bone in mice, and type I immune cells were remanufactured by hematopoietic stem cells to recombine the immune systemIn previous bone marrow transplants, hematopoietic stem cells were difficult to implant into the recipient's boneIn addition to immune disorders, the host's hematopoietic stem cells occupy the right growing environment, and the donor's hematopoietic stem cell implantation is limitedTherefore, before receiving a bone marrow transplant, some toxic side effects need to be pre-treated to cause autoimmune cells to lose their activity, otherwise autoimmune cells will attack the newly transplanted foreign cellsHowever, chemotherapy can also destroy stem cells in the body, causing hair loss, diarrhea, mental decline and other side effectsAccording to Owen Weissman, an immunologist at the School of Medicine, antibodies not only attackdiseases
such as sickle-like blood cells, severe immunodeficiency, re-impairment anemia and thalassemia, but also remove hematopoietic stem cellsInitially, immune cells may reject the transplanted bone marrow, and the patient needs to receive antibodies to suppress the immune cells, which may cause cold-like symptoms or other side effectsAfter that, the antibodies will clear up space for new stem cellsAlthough this is a very tempting method, any remaining host hematopoietic stem cells will compete for space with newly implanted cells, and may even produce T-cells to attack transplanted cellsCurrently, researchers are looking for a suitable human antibody for experimentsIf successful, this method will provide a mild and suitable growth environment for newly transplanted bone marrow, successfully produce new red blood cells and white blood cells, and cure the difficultof traditional medicinesuch medicines such as sickle cellemia, type 1 diabetes, polypherosclerosis, and lupus(Chang Lijun)