U.S. scientists find fatal weakness in lung cancer cells

a U.Steam of researchers recently found that if a key gene called "14-3-3 Jetta" in lung cancer cells cannot be expressed, it will be difficult for cancer cells to "live." Scientists say the gene could be a target for new drugs for lung cancer treatmentsWriting in the new issue of the Proceedings of the National Academy of Sciences, scientists from Emory University and others say they are targeting the "14-3-3 Jetta" gene because it is active in many lungtumorscellsAnd other recent studies have found that lung cancer patients have a lower survival rate if the gene is overexpressed in the lungtumorcells,they use RNA(
RIFR) intervention techniques to"silence" the "14-3-3 Jetta" gene, said Fu Hai'an, a Chinese scientist at emory university in, who led the studyExperiments show that,the gene is "silent" after the , lung cancer cells to form a new tumor colonization ability significantly reduced , ability to expand impaired Fu Haian explained that after the "14-3-3 Jetta" gene cannot be expressed, lung cancer cells themselves do not grow significantly slower, but they are more likely to "lose their nest and die." The so-called "lost nest apoptosis" is a special type of cell procedural death that occurs in normal cells, that is, cells and extracellular matrix and other cells separate, become helpless and induce death Often, one of the most important characteristics of cancer cells is that they can grow and survive on their own, even if they are not related to the surrounding cells However, the "14-3-3 Jetta" gene can not be expressed, making lung cancer cells become extremely fragile, but also prone to "nest apoptosis." Lung cancer is one of the most deadly cancers, but there are very few options available in the treatment of lung cancer Fu Haian said that after determining the "14-3-3 Jetta" gene, scientists are expected to develop a new type of lung cancer treatment based on the base