Urine protein markers associated with progression of gastric mucosal lesions and early gastric cancer risk

November 8, 2022 ， Li Wenqing's research team at Peking University Cancer Hospital et al.
in the Lancet series of journals EbioMedicine（ IF:11.
205） A research paper entitled "Urine proteomic signatures predicting the progression from premalignancy to malignant gastric cancer" was published online
。 In this study, the urine proteomics map of gastric mucosal lesions evolving to various stages of gastric cancer was systematically delineated&#xff0c.
A group of urine proteins &#xff0c significantly associated with gastric mucosal lesion progression and gastric cancer risk were screened; It provides an important reference
for the accurate identification, early screening and early diagnosis of potential gastric cancer risk groups.

Gastric cancer onset is insidious ， Low early detection rate ， Identification and early diagnosis of high-risk populations remains challenging
.
Non-invasive biomarker detection is of great significance
for effectively identifying high-risk groups of gastric cancer, carrying out gastric cancer grading intervention, improving early detection rate, and improving the prognosis of gastric cancer.
This study relied on subjects from Linqu County, Shandong Province who participated in the National Early Diagnosis and Treatment Program for Upper Gastrointestinal Cancer and patients attending Peking University Cancer Hospital&#xff0c.
A total of 255 patients with different grades of gastric mucosal lesions and gastric cancer were enrolled in two stages， and clearly did not have kidney or urinary diseases， Collection of mid-morning urine for urine proteomics testing， Among them, the first phase of the study subjects （ n=123） Gastric mucosal tissue from the highest diagnostic site is also collected for histoproteomic testing
.
The study found ， There are significant differences in the urine proteomic profiles of gastric cancer and precancerous lesions
.
After screening 43 differential urine proteins for gastric cancer and gastric mucosal lesions in two-stage analysis， Further through prospective gastroscopy follow-up of 60 subjects， Four key urine protein&#xff08 that were significantly positively correlated with the progression of gastric mucosal lesions and gastric cancer were identified.
ANXA11, CDC42, NAPA, and SLC25A4）
。 tissue and urine proteomics integration analysis findings， Although the overall association between urine protein and tissue-level levels was low ， but &#xff0c in differential urine protein; About two-thirds are associated with gastric cancer at the tissue and urine levels； Three of the four key urine proteins were also positively correlated
with gastric cancer risk at the tissue level.
The integration of four key urine proteins significantly improved the ability
to predict the progression of gastric mucosal lesions and the risk of gastric cancer.

Case-control studies combined with prospective cohort studies were used in this study， The molecular characteristics of urinary protein associated with the evolution of gastric mucosal lesions to gastric cancer&#xff0c were clarified.
It provides important evidence
for the identification and early diagnosis of high-risk groups of gastric cancer based on non-invasive detection.
Prof.
Wenqing Li, Peking University Cancer Hospital, National Center for Protein Science（ Beijing） Professor Qin Jun, Professor Pan Kaifeng of Peking University Cancer Hospital and Professor Wu Jianmin of Bioinformatics Center are co-corresponding authors of the paper&#xff0c.
Fan Hua, a 2022 master's graduate from the Epidemiology Laboratory of Peking University Cancer Hospital, and Xue Li, a doctoral graduate, are co-first authors
of the paper.

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