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Accurate single virus detection is essential for disease diagnosis and early prevention, especially in light of the current COVID-19 pandemic
.
There are many detection methods that are sensitive to a single virus, including optical methods and immunological detection methods
This kind of equipment can control the light into "tweezers", accurately "move" a single virus, and aim it at a specific part of the cell, which is helpful for the development of new methods for disease diagnosis and virus research, and for the development of vaccines.
Because the device allows scientists to isolate damaged or incomplete viruses from thousands of other samples in one minute, and the current process is cumbersome and lacks precision
.
One of the research leaders, Eric Yap, associate professor of Nanyang Technological University’s Lee Kong Chian School of Medicine, said: “The current traditional method of analyzing viruses is to study thousands or millions of virus populations
.
We only know them as the average behavior of the entire population.
The researchers tested a device called a "digital virus manipulation chip" on adenoviruses with a diameter of 90 to 100 nanometers (nanometers)
.
Adenovirus is a common virus that can cause cold-like symptoms
Professor Liu Aiqun of Nanyang Technological University, who led the research, said: "Our invention uses light to manipulate viruses in a certain size range.
We have proven that it is effective against adenovirus
.
" We believe that our equipment can also be used to capture and concentrate SARS- CoV-2 is used for research and diagnosis
This is a "light" method of manipulating viruses very precisely
The device is 2 cm long and 2 cm wide, about the size of a thumb nail.
It consists of a chip made of silicon oxide and silicon nitride wafers.
The working principle of the device is to load the virus-containing liquid such as blood into the chip
.
Then, a laser beam is directed at it, forming a spot of light
Professor Liu said: "Our invention is a breakthrough in virus research.
It allows us to select individual samples for research.
The current similar technology can only handle a large number of viruses
.
For example, we can isolate a single virus with mutations to develop Therapies for these mutations
Professor Yapu added: “Using this technology, we can carefully select specific virus particles and conduct research on them to obtain new insights into them and the diseases they cause
.
For example, it can be used to analyze specific virus particles in more detail.
Scientists are working to expand its use
.
For example, they are studying how the device guides the isolated virus to infect the target part of human cells
.
The team said that this will lead to the progress of virus research and improve the efficiency of vaccine and antiviral drug development
.
