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When the immune system reacts incorrectly and attacks an individual's own body, an autoimmune disease occurs
Researchers from Uppsala University in Sweden, Karolinska Institutet, and Osaka City University in Japan took the opposite approach in a study: They focused on suspected autoantigens, and then performed matching diseases.
"In the end, we found a match," Niels Landgren, a doctor and researcher at Uppsala University who specializes in autoimmune diseases and an affiliated researcher at the Solna Department of Medicine at Karolinska Institutet, led the study
Paraneoplastic pemphigus is a serious autoimmune bullous disease characterized by pleomorphic skin and mucosal lesions associated with neoplastic diseases
Through this report on TGM1 autoantibodies in paraneoplastic pemphigus, researchers demonstrated an unconventional biomarker discovery method, starting from a putative autoantigen, based on the expression profile and function of the protein under study To explore a range of diseases
This study illustrates a new method of identifying biomarkers