It is a pathogenic microorganism that grows strictly within the cell between bacteria and viruses, and has a complex mechanism to survive in its infectious inclusion bodies
Together they constitute the most critical components of the cytoskeleton: actin filaments and microtubules (MTs)
The chlamydial protein Tarp (translocation actin recruiting protein) is injected into the host cytoplasm through the Chlamydia type III secretion system by attaching to the plasma membrane at first, and invades the host cell
, When the microtubules are assembled around the inclusion body,
These scaffolds are then stabilized and undergo post-translational modifications (PTM), including detyrosinase and acetylation
Chlamydia
Leave the host cell by controlling cell lysis or extrusion, which also depends on the intervention of the host cytoskeleton
Chlamydia
Infection
Chlamydia Research
It is significantly limited due to its dependence on cytoskeleton modulating drugs
In general, the study confirmed that a single Chlamydia effector, InaC, is
Chlamydia
Infect
Major regulators of actin and microtubule dynamics during the period
.
This study provides the first evidence that the chlamydia effector InaC influences the interaction of ARF1-RhoA to manipulate the host cytoskeleton
.
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