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Tumor targeting: inducing apoptosis of cancer cells in T-cell acute lymphoblastic leukemia

 Last Update: 2021-11-14
 Source: Internet
 Author: User

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Acute lymphocytic leukemia (ALL) is a common childhood cancer

Mitochondrial activated kinase MAP2K7 is a new target for anticancer drug therapy

The only downstream substrate of MAP2K7 is JNK.

The compound 5Z-7-oxozeaenol (5Z7O) can bind to the cysteine-218 position of MAP2K7, although it can also inhibit other kinases such as TAK1

The Lacorazza research team at Baylor College of Medicine mentioned in their Oncotarget study summary: “We have provided proof-of-principle data to support the targeting of the MAP2K7 pathway in children’s T-ALL

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