Tumor immune efficacy is very different the original "super-enhancers" in the making

immunosuppressive therapy is one of the most promising treatments for tumors. However, the treatment in different groups, different tumors, different individuals, the efficacy of great differences. Reporter 15 from Nantong University was informed that the university's researchers found a new piece of DNA, named "super-enhancer" PD-L1L2-SE, it can allow cancer cells to escape immune attacks. The discovery of this mechanism provides a new entry point for understanding how cancer cells escape immune system attack, opens up a new therapeutic pathway for cancer immunotherapy, and is an important breakthrough in the field of cancer immunotherapy. The results have been published in cell communications, a sub-issue of Cells.Tumor has become one of the most important diseases affecting human health because of its high morbidity and mortality. Former U.S. President Jimmy Carter, who was diagnosed with malignant melanoma at the age of 90, has not been effective in trying many traditional treatments. Six months later, however, President Carter's tumor was completely relieved because he had used a new treatment, immunosuppressive therapy.In view of the widely differing efficacy of immunotherapy, it is generally accepted in the scientific community that finding more effective regulatory means for key targets PD-L1 and L2 is the most important way to treat tumors. Through bio-informational analysis, Professor Fan Yihui and Professor Mao Renfang of Nantong University found abnormal expressions of PD-L1 and PD-L2 in cancer cells because cancer cells opened up a closed fragment of DNA, which is located in the middle of the PD-L1 and PD-L2 encoded genes and is named "Super Enhancer" PD-L1L2-SE. The abnormal activation of the DNA fragment allows tumor cell abnormal expression of both PD-L1 and PD-L2 twin media, thus activating the PD-1 complex on T cells, inhibiting the killing of tumor cells by T cells, and helping tumor cells evade immune attacks. Therefore, inhibiting the activity of the DNA fragment and breaking the "barrier" set by tumor cells can help T cells effectively kill tumor cells, providing the possibility for effective treatment of tumor diseases. (Science and Technology Daily)