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Cachexia is a disease in which tumors induce muscle and body fat consumption.
Image source: https:// in a research report entitled "Tumor-derived MMPs regulate cachexia in a Drosophila cancer model" published in the international journal Developmental Cell, scientists from Australia’s Peter McAllen Cancer Center and other institutions The fly (Drosophila melanogaster), as a model for studying cancer cachexia, found that tumors secrete an enzyme called Mmp1, which is mainly responsible for breaking down fat and muscle
Researcher Louise Cheng said that Drosophila and humans share 70% of genes.
Tumor-derived MMPs may regulate the progression of cachexia in cancer patients
Image source: William Lodge, et al.
By digging the cancer genome map, the researchers found that high levels of Mmp enzyme may be directly related to the occurrence of cachexia in cancer patients; therefore, the researchers are likely to find a mediator related to human cachexia; they hope that the research in this article may help They develop new tools for the early diagnosis of cachexia and identify therapies that may be able to treat this condition
At the same time, understanding the causes of muscle and fat breakdown will also help researchers find new ways to save normal tissues in cancer patients.
Original source:
William Lodge, Michael Zavortink, Sofia Golenkina, et al.
