Transl Psychiatry: A variety of blood test indicators are closely related to the incidence of dementia

Dementia prevention is a public health priority, and identifying potential biomarkers may provide benefits for early detection and prevention

Dementia is a collection of largely irreversible neurological diseases characterized by memory loss, cognitive impairment, and difficulties in activities of daily living that significantly reduce quality of life and cause a huge social burden

With the increasing prevalence of dementia and the lack of effective treatments, current trends suggest a need to identify novel biomarkers and search for modifiable risk factors to combat the dementia epidemic non-invasively

In addition, the effects of common laboratory tests were examined in areas other than dementia

Recently, the team of Yu Jintai from Huashan Hospital Affiliated to Fudan University published important research results in Transl Psychiatry, using data from the UK Biobank (UKB) to comprehensively explore which systemic diseases may be prone to dementia, providing a powerful way to overcome traditional limitations.

This study investigated the association of common serum laboratory tests with the risk of developing dementia

Linear relationship between serum laboratory tests and risk of developing dementia

Nonlinear association between serum laboratory tests and risk of developing dementia

Heatmap outlining the association of serum laboratory tests with dementia risk

The study found that dementia incidence was significantly associated with low vitamin D concentrations (hazard ratio 0.

In conclusion, vitamin D deficiency, disturbance of the GH-IGF-1 axis, lack of sex hormone bioactivity, decreased liver function, renal abnormalities, oxidation, insulin resistance, immune dysregulation, and lipid dysregulation are associated with the pathogenesis of dementia

original source

He XY, Kuo K, Yang L, et al.

https://doi.