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Uncontrolled bleeding remains one of the leading causes of preventable post-injury death
prevention
Figure 1: Selection process flow chart
Figure 1: Selection process flow chartRandomized controlled trials (RCTs) of hemorrhagic trauma patients (age ≥16 years) who received platelet transfusions between 1946 and October 2020 were screened from Pubmed, Medline, and Embase
thrombus
Figure 1: The overall quality of the studies was moderate, as shown in Figure 2
Figure 1: The overall quality of the studies was moderate, as shown in Figure 2
n
Figure 2: High platelet:plasma, but not high plasma:RBC ratio increases 24-hour and 30-day mortality in randomized controlled trials
Figure 2: High platelet:plasma, but not high plasma:RBC ratio increases 24-hour and 30-day mortality in randomized controlled trials
Figure 3: High platelet:erythrocyte ratio has no effect on thromboembolic events or organ failure in trauma patients in randomized controlled trials
Figure 3: High platelet:erythrocyte ratio has no effect on thromboembolic events or organ failure in trauma patients in randomized controlled trials
However, this systematic review also has several limitations, such as the method of calculating the platelet:erythrocyte ratio, resulting in possible overlap of transfusion ratios in the high-ratio and low-ratio groups, which may affect the analysis
Original source:
Kleinveld DJB, van Amstel RBE, Wirtz MR, Geeraedts LMG, Goslings JC, Hollmann MW, Juffermans NP.
Kleinveld DJB, van Amstel RBE, Wirtz MR, Geeraedts LMG, Goslings JC, Hollmann MW, Juffermans NP.
Platelet-to-red blood cell ratio and mortality in bleeding trauma patients: A systematic review and meta-analysis.
Transfusion.
2021 Jul; 61 Suppl 1(Suppl 1): S243-S251.
doi: 10.
1111/trf.
16455.
PMID: 34269443; PMCID: PMC8362120.
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