Tragedy! Nature shows that blood cell mutations associated with leukemia are inevitable and there are human differences!

, June 27, 2020 /PRNewswire-BIOON/-- A new study by researchers at the Center for Integrated Medical Center (RIKEN IMS) of the Japan Institute of Science and Science has looked at the differences in blood cell mutations in Japanese and EuropeansThe study found that these preclinical mutations were associated with different types of cancer, which could explain why Europeans had a higher rate of chronic lymphocyteleukemia, while the Japanese had a higher rate of T-leukemiaThe study was published June 24 in the journal Natureour blood cells are constantly being updated from stem cells that arestem cells located in the bone marrowThesestem cellsproduce progenitor cells of many different types of blood cellsThese include the important lymphocytes that make up our immune system, such as T-cells and B-cellsBlood cells from the samestem cellsor progenitor cells can be identified by looking at their DNAFor example, all T cells come from a particular HSC, which is cloned on one anotherIf the HSC mutates, the same mutation will exist in all T cells in that cell line, but not in other T cells from different HSCsphoto source: RIKEN
Although these types of cloning mutations have been studied in European populations, Chikashi Terao and his team at RIKEN IMS suspect they may find some different results among nearly 180,000 elderly people in JapanTheir results showed that 35 percent of people in their 90s had a clone mutationData from the UK's Biobank yielded similar results, but the overall percentage was lower"Our findings strongly suggest that chromosomal changes in hematopoietic cloning are inevitable in very older people," Terao saidThe higher mutation rate in the Japanese population may be related to the larger average age of the sample"
however, a more in-depth comparison of the data from the UK Biobank revealed some differencesThe team looked at all the mutations in the T-cell lineage and found that more than 80 percent of the mutations occurred in Japanese peopleOn the other hand, more than 90% of B-cell mutations occur in European samplesThese figures are consistent with reported cases of leukemiaJapanese people are 10 times more likely to develop T-cell leukemia than Europeans, while chronic lymphocytic leukemia, a type of B-cell-related leukemia, is five times more common among Europeans than in JapanThis does not mean that mutations occur selectively in different genes, depending on the populationKeep in mind that this data only includes survival and replication of cloned mutations that are sufficient to be detected"We can infer that the advantages of a particular chromosomal mutation depend on the geneticand environmental background of the ," Terao explains "
researchers also found genetic components associated with the risk of HSC cloned mutations They identified several locations on the chromosomes where genetic mutations are generally associated with increased risk of cloned blood mutations, and three locations associated with specific mutations in B cells This means that by looking for these mutations in a person's DNA, the likelihood or risk of a critical mutation now or in the future can be estimated , so while cloned HSC mutations may be unavoidable, there are still things we can do "Not everyone with these mutations gets cancer," Terao stressed However, you can get a simple blood test in any routine health exam that will identify people at risk of leukemia by examining the cloned HSC mutation DNA tests based on blood samples can also identify people at high risk who are at high risk for future critical HSC mutations " (biovalleybioon.com) reference: Blood Cell mutations linked to leukemias are eos a weage Chromosomal-hallia-mog-haematopoietic clones in the , Nature (2020) DOI: 10.1038/s41586-020-2426-2
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