Traditional Chinese medicine compound can effectively delay the progression of rheumatoid and improve the prognosis of patients

▼Medical guidance: Professor Huang Runyue , Department of Rheumatology and Immunology, Guangdong Provincial Hospital of Traditional Chinese Medicine

▼ medical guidance: Guangdong Provincial Hospital of rheumatoid immune Division Huang leap month immunization Professor Professor

Rheumatoid patients usually need regular blood tests, including rheumatoid factor, anti-cyclic citrulline antibody, C-reactive protein, and erythrocyte sedimentation rate to diagnose rheumatoid arthritis and assess disease activity
.

diagnosis

As we all know, the diagnosis of rheumatoid arthritis mainly relies on characteristic clinical manifestations, laboratory tests and imaging examinations
.

The conventional laboratory diagnostic indicators mainly include: rheumatoid factor and anti-cyclic citrulline antibodies

Rheumatoid factor Rheumatoid factor anti-cyclic citrulline antibody Anti-cyclic citrulline antibody

Recently, the Rheumatology and Immunology Physicians Branch of the Chinese Medical Doctors Association formulated the "Expert Consensus on the Clinical Application of Rheumatoid Arthritis-related Autoantibodies " [1] , which provides a reference for the correct application and interpretation of rheumatoid arthritis-related autoantibodies
.

Consensus [1] Interpretation

Let's interpret the relationship between rheumatoid factor, anti-cyclic citrulline antibody and rheumatoid arthritis and its clinical significance
.

The relationship between rheumatoid factor, anti-cyclic citrulline antibody and rheumatoid arthritis and its clinical significance

The relationship between rheumatoid factor, anti-cyclic citrulline antibody and rheumatoid arthritis

The relationship between rheumatoid factor, anti-cyclic citrulline antibody and rheumatoid arthritis

Rheumatoid factor has good sensitivity to the diagnosis of rheumatoid arthritis.
The positive rate of rheumatoid factor in patients with rheumatoid arthritis is 60-80%.
The detection of rheumatoid factor can include different types of antibodies such as IgM, IgG and IgA
.

Rheumatoid factor has good sensitivity to the diagnosis of rheumatoid arthritis Rheumatoid factor has good sensitivity to the diagnosis of rheumatoid arthritis

High titer rheumatoid factor IgM is related to the progression and poor prognosis of rheumatoid arthritis;

IgG and rheumatoid factor in rheumatoid arthritis synovitis, vascular inflammation and joint symptoms associated;

Blood vessel

Rheumatoid factor IgA is related to the severity of arthritis symptoms and bone destruction in patients with rheumatoid arthritis
.

Anti-cyclic citrulline antibody has good sensitivity and specificity for the diagnosis of rheumatoid arthritis.
It can be positive in the early stage of rheumatoid arthritis and has a high positive predictive value
.

Domestic and foreign literatures have reported that anti-cyclic citrulline antibodies are closely related to the severity of the disease, especially the erosive changes in imaging (ie, bone destruction)

Anti-cyclic citrulline antibody has good sensitivity and specificity for the diagnosis of rheumatoid arthritis Anti-cyclic citrulline antibody has good sensitivity and specificity for the diagnosis of rheumatoid arthritis

Rheumatoid factor and anti-cyclic citrulline antibodies are not only of great significance in the early diagnosis of rheumatoid arthritis, but the higher the titer also means that the disease is easy to develop in the direction of bone destruction
.

Therefore, it can be used as a predictor of the progression and prognosis of rheumatoid arthritis joint damage

And the higher the titer also means that the disease is easy to develop in the direction of bone destruction, and the higher the titer also means that the disease is easy to develop in the direction of bone destruction.

The role of traditional Chinese medicine in the treatment of rheumatoid arthritis, reducing rheumatoid factor and anti-cyclic citrulline antibodies

Traditional Chinese medicine is China's traditional medicine, and it also has a long history in the treatment of rheumatoid arthritis
.

So what kind of improvement can Chinese medicine treatment of rheumatoid arthritis bring to patients? Does it have any effect in reducing rheumatoid factor and anti-cyclic citrulline antibodies?

Traditional Chinese medicine is China's traditional medicine, and it also has a long history in the treatment of rheumatoid arthritis

Professor Huang Runyue's team from Guangdong Provincial Hospital of Traditional Chinese Medicine published a paper in the internationally renowned journal "Frontiers in Pharmacology" (IF: 5.

This article included 65 randomized controlled studies on the treatment of rheumatoid arthritis with Chinese herbal compound to evaluate whether Chinese herbal compound can reduce serum rheumatoid factor and anti-cyclic citrulline antibody levels
.

Finally, we found that if the syndrome differentiation is accurate, the individualized Chinese herbal compound treatment for rheumatoid arthritis has the potential to reduce the level of rheumatoid factor and anti-cyclic citrulline antibody .
The Chinese herbal compound alone or combined with western medicine may be more beneficial than western medicine alone.
Good efficacy
.

If accurate differentiation, individualized treatment of rheumatoid arthritis herbal composition having a reduced potential role of rheumatoid factor and anti-cyclic citrullinated antibody levels if accurate differentiation, individualized herbal composition having reduced Treatment of Rheumatoid Arthritis and rheumatoid factor Potential effects of anti-cyclic citrulline antibody levels

In addition, the traditional Chinese medicine compound group also showed certain advantages compared with the western medicine group in terms of the ACR remission rate after treatment
.

This suggests that TCM syndrome differentiation is an effective treatment method for rheumatoid arthritis , a potential and effective adjuvant treatment to delay the progression of rheumatoid arthritis and improve the prognosis of patients

TCM syndrome differentiation is an effective treatment method for rheumatoid arthritis.

This greatly enhances the determination of traditional Chinese medicine practitioners to inherit, develop, and make good use of traditional Chinese medicine.

Provide more professional and effective treatment for patients with rheumatoid arthritis! Provide more professional and effective treatment for patients with rheumatoid arthritis!

references:

references:

[1] Autoantibody Detection Professional Committee of Chinese Medical Doctor Association Rheumatology and Immunology Physician Branch.

[1] Autoantibody Detection Professional Committee of Chinese Medical Doctor Association Rheumatology and Immunology Physician Branch.

[2] Tang, X, Liu, Z, Yang, Z, Xu, S, Wang, M, Chen, X et al.
The Effect of Chinese Medicine Compound in the Treatment of Rheumatoid Arthritis on the Level of Rheumatoid Factor and Anti- Cyclic Citrullinated Peptide Antibodies: A Systematic Review and Meta-Analysis.
Frontiers in Pharmacology 2021;12:1633.

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